Fungicidal Effect of Resveratrol on Human Infectious Fungi
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Resveratrol, a phenolic antioxidant found in grapes, has been known to mediate various biological activities on the human body. In the present study, we tested the antifungal activity of resveratrol against human pathogenic fungi before carrying out further studies to elucidate the antifungal mechanism(s) of resveratrol. Resveratrol displayed potent antifungal activity against human pathogenic fungi at concentration levels of 10–20 μg/mL Furthermore, time-kill curve exhibited fungicidal effect of resveratrol on C. albicans, but the compound had no hemolytic activity against human erythrocytes. The destruction of C. albicans cells by resveratrol was confirmed by scanning electron microscopy. These results suggest that resveratrol could be employed as a therapeutic agent to treat fungal infections of humans.
Key wordsResveratrol trans-3,5,4’-Trihydroxystilbene Phenolic antioxidant Fungicidal activity Hemolytic effect
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- Gronbaek, M., Deis, A., Sorensen, T. I., Becker, U., Schnohr, P., and Jensen, G., Mortalilty associated with moderate intakes of wine, beer, or spirits.Br. Med. J., 310, 1165–1169 (1995).Google Scholar
- Jahn, B., Martin, E., Stueben, A., and Bhakdi, S., Susceptibility testing ofCandida albicans andAspergillus species by a simple microtiter menadione-augmented 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay.J. Clin. Microbial., 33, 661–667 (1995).Google Scholar
- Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., and Pezzuto. J. M., Cancer chemopreventive activity of resveratrol, a natural product derived from grapes.Science, 275, 218–220 (1997).PubMedCrossRefGoogle Scholar
- Lee, D. G., Park, Y., Kim, H. N., Kim, H. K., Kim, P. I., Choi, B. H., and Hahm, K. -S., Antifungal Mechanism of an Antimicrobial Peptide, HP(2-20), Derived from N-Terminus ofHelicobacter pylori Ribosomal Protein L1 againstCandida albicans.Biochem. Biophys. Res. Commun., 293, 231–238 (2002).PubMedCrossRefGoogle Scholar
- Pace-Asciak, C. R., Hahn, S., Diamandis, E. P., Soleas, G., and Goldberg, D. M., The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implications for protection against coronary heart disease.Clin. Chim. Acta, 235, 207–219 (1995).PubMedCrossRefGoogle Scholar