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Archives of Pharmacal Research

, Volume 28, Issue 5, pp 557–560 | Cite as

Fungicidal Effect of Resveratrol on Human Infectious Fungi

  • Hyun Jun Jung
  • In Ah Hwang
  • Woo Sang Sung
  • Hyungu Kang
  • Beom Sik Kang
  • Young Bae Seu
  • Dong Gun Lee
Article

Abstract

Resveratrol, a phenolic antioxidant found in grapes, has been known to mediate various biological activities on the human body. In the present study, we tested the antifungal activity of resveratrol against human pathogenic fungi before carrying out further studies to elucidate the antifungal mechanism(s) of resveratrol. Resveratrol displayed potent antifungal activity against human pathogenic fungi at concentration levels of 10–20 μg/mL Furthermore, time-kill curve exhibited fungicidal effect of resveratrol on C. albicans, but the compound had no hemolytic activity against human erythrocytes. The destruction of C. albicans cells by resveratrol was confirmed by scanning electron microscopy. These results suggest that resveratrol could be employed as a therapeutic agent to treat fungal infections of humans.

Key words

Resveratrol trans-3,5,4’-Trihydroxystilbene Phenolic antioxidant Fungicidal activity Hemolytic effect 

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Copyright information

© The Pharmaceutical Society of Korea 2005

Authors and Affiliations

  • Hyun Jun Jung
    • 2
  • In Ah Hwang
    • 2
  • Woo Sang Sung
    • 2
  • Hyungu Kang
    • 2
  • Beom Sik Kang
    • 1
  • Young Bae Seu
    • 2
  • Dong Gun Lee
    • 2
  1. 1.School of Life Science College of Natural SciencesKyungpook National UniversityTaeguKorea
  2. 2.Department of MicrobiologyKyungpook National UniversityTaeguKorea

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