Free Radical Scavenging and Hepatoprotective Constituents from the Leaves of Juglans sinensis
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In the course of searching for hepatoprotective agents from natural products, six compounds were isolated from the MeOH extract of the leaves of Juglans sinensis, as guided by their DPPH free radical scavenging activity. The structures were determined as juglanoside B (1), quercetin 3-O-α-L-arabinofuranoside (avicularin, 2), quercetin 3-O-α-L-arabinopyranoside (guaijaverin, 3), quercetin 3-O-α-L-rhamnopyranoside (quercitrin, 4), (+)-catechin (5) and quercetin 3-O-β-D-galactopyranoside (hyperin, 6). Compounds 2-6 showed significant DPPH free radical scavenging effects. An evaluation for the hepatoprotective activity of the isolated compounds on drug-induced cytotoxicity was conducted, and compounds 1, 2, and 5 showed protective effects against nitrofurantoin-induced cytotoxicity, and compound 5 also exhibited a moderate protective effect on amiodarone-induced cytotoxicity in Hep G2 cells.
Key wordsJuglans sinensis Juglandaceae Hepatoprotective Hep G2 Cells Free radical scavenging
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