Advertisement

Archives of Pharmacal Research

, Volume 28, Issue 2, pp 172–176 | Cite as

Butyrylcholinesterase inhibitory guaianolides fromAmberboa ramosa

  • Sher Bahadar Khan
  • Azhar-ul-Haq
  • Shagufta Perveen
  • Nighat Afza
  • Abdul Malik
  • Sarfraz Ahmad Nawaz
  • Muhammad Raza Shah
  • Muhammad Iqbal Choudhary
Drug design

Abstract

Phytochemical investigation of the whole plant of Amberboa ramosa led to the isolation of six sesquiterpene lactones which could be identified as 8α-hydroxy-11β-methyl-1αH, 5αH, 6βH, 7αH, 11αH-guai-10(14), 4(15)-dien-6, 12-olide(1), 3β 8α-dihydroxy-11α-methyl-1αH, 5αH, 6βH, 7αH, 11βH-guai-10(14), 4 (15)-dien-6, 12-olide (2), 3β, 4α, 8α-trihydroxy-4β-(hydroxymethyl)-1αH, 5αH, 6βH, 7αH-guai-10(14), 11(13)-dien-6, 12-olide (3), 3β, 4α, 8α-trihydroxy-4β-(chloromethyl)-1αH, 5αH, 6βH, 7αH-guai-10(14),11(13)-dien-6, 12-olide(4), 3β, 4α, dihydroxy-4β-(hydroxymethyl)-1αH, 5αH, 6βH, 7αH-guai-10(14),11(13)-dien-6, 12-olide(5), 3β, 4α-dihydroxy-4β-(chloromethyl)-8α-(4-hydroxymethacrylate)-1αH, 5αH, 6βH, 7αH-guai-10(14),11 (13)-dien-6,12-olide (6) by spectroscopic methods. All of them showed inhibitory potential against butyrylcholinesterase.

Key words

Amberboa ramosa Compositae Guaianolides Butyrylcholinesterase inhibition 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Akhtar, N., Malik, A., Afza, N., and Badar, Y., Cycloartane type triterpenes fromAmberboa ramosa.J. Nat. Prod, 56, 295–299(1993).CrossRefGoogle Scholar
  2. Ellman, G. L., Courtney K. D., Andres, V., and Featherstone, R. M., A new and rapid colorimetric determination of acetylcholinesterase activity.Biochem. Pharmacol., 7, 88–95 (1961).PubMedCrossRefGoogle Scholar
  3. Fernandez, I., Garcia, B., Grancha, F. J., and Pedro, J. R., Sesquiterpenes lactones, flavonoids and coumarins fromCentaurea collina.Phytochemistry, 28,2405–2407 (1989).CrossRefGoogle Scholar
  4. Harrison, D. A. and Kulshrestha, D. K., Chemical constituents ofAmberboa ramosa. Fitoterapia, LV, 189-192 (1984).Meyer, B. N., Ferrigni, N. R., Putnam, J. E., Jacobsen, L. B., Nichols, D. E., and McLaughlin, J. L., Brine shrimp: A convential general bioassay for active plant constituents.Planta Med., 45, 31 -34 (1982).CrossRefGoogle Scholar
  5. Huikang, W., Zhangdia, I., Kan, H., and Shuwen, W., Studies on the chemical constituents ofSaussurea involucrate.Yaoxue Xuebao, 21,680–682 (1986).Google Scholar
  6. Oksuz, S., Serin, S., and Topcu, G., Sesquiterpene lactones fromCentaurea hermanii.Phytochemistry, 35, 435–438 (1994).CrossRefGoogle Scholar
  7. Schwarz, M., Glick, D., Loewensten, Y., and Soreq, H., Engineering of human cholinesterases explains and predicts diverse consequences of administration of various drugs and poisons.Pharmacol. Ther, 67, 283–322 (1995).PubMedCrossRefGoogle Scholar
  8. Silver A., The Biology of Cholinesterases. North Holland Publishing Comp.,Amsterdam Elsevier (1974).Google Scholar
  9. Singh, P. and Bhala, M., Guaianolides fromSaussurea candicans.Phytochemistry, 27,1203–1205 (1988).CrossRefGoogle Scholar
  10. Singhal, A. K., Chowdhury, P. K., Sharma, R. P., Baruah, J. N., and Herz, W., Guainolides fromTricholepis glaberrima.Phytochemistry, 21,462–463 (1982).CrossRefGoogle Scholar
  11. Youssef, D. and Frahm, A. W., Constituents of the EgyptianCentaurea scoparia; chlorinated guainolides of the aerial part.Planta Med, 60,267–270 (1994).PubMedCrossRefGoogle Scholar
  12. Yu, S. Q., Holloway, H. W., Utsuki, T., Brossi, A., and Greig, N. H., Synthesis of novel phenserinebasedselective inhibitors of butyrylcholinesterase for Alzheimers disease.J. Med. Chem., 42,1855–1861 (1999).PubMedCrossRefGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 2005

Authors and Affiliations

  • Sher Bahadar Khan
    • 2
  • Azhar-ul-Haq
    • 2
  • Shagufta Perveen
    • 2
  • Nighat Afza
    • 1
    • 2
  • Abdul Malik
    • 2
  • Sarfraz Ahmad Nawaz
    • 2
  • Muhammad Raza Shah
    • 2
  • Muhammad Iqbal Choudhary
    • 2
  1. 1.Pharmaceutical Research CentrePCSIR Labs Complex KarachiKarachiPakistan
  2. 2.International Centre for Chemical Sciences, H.E.J. Research Institute of ChemistryUniversity of KarachiKarachiPakistan

Personalised recommendations