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Archives of Pharmacal Research

, Volume 28, Issue 4, pp 400–404 | Cite as

Monoamine oxidase inhibitory naphthoquinones from the roots ofLithospermum erythrorhizon

  • Woo Hoi Choi
  • Seong Su Hong
  • Seon A Lee
  • Xiang Hua Han
  • Kyong Soon Lee
  • Myung Koo Lee
  • Bang Yeon Hwang
  • Jai Seup Ro
Drug design

Abstract

Activity-guided fractionation of a hexane-soluble extract of the roots ofLithospermum erythrorhizon, using a mouse brain monoamine oxidase (MAO) inhibition assay, led to the isolation of two known naphthoquinones, acetylshikonin and shikonin, and a furylhydroquinone, shikonofuran E. These compounds were shown to inhibit MAO with IC50 values of 10.0, 13.3, and 59.1 μM, respectively. Although no specificity for MAO-A and MAO-B was shown by acetylshikonin and shikonin, a Lineweaver-Burk plot analysis indicated that the inhibition was competitive for both MAO-A and MAO-B activity.

Key words

Lithospermum erythrorhizon Boraginaceae Naphthoquinone Monoamine oxidase inhibitor 

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Copyright information

© The Pharmaceutical Society of Korea 2005

Authors and Affiliations

  • Woo Hoi Choi
    • 1
  • Seong Su Hong
    • 1
  • Seon A Lee
    • 1
  • Xiang Hua Han
    • 1
  • Kyong Soon Lee
    • 1
  • Myung Koo Lee
    • 1
    • 2
  • Bang Yeon Hwang
    • 1
  • Jai Seup Ro
    • 1
  1. 1.College of PharmacyChungbuk National UniversityCheongjuKorea
  2. 2.Research Center for Bioresource and HealthChungbuk National UniversityCheongjuKorea

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