Archives of Pharmacal Research

, Volume 30, Issue 5, pp 552–555 | Cite as

a new cytotoxic phenazine derivative from a deep sea bacteriumBacillus sp.

  • Dehai Li
  • Fengping Wang
  • Xiang Xiao
  • Xiang Zeng
  • Qian- Qun Gu
  • Weiming Zhu
Articles Drug Design


A novel phenazine derivative (1) together with six known compounds (2–7) were isolated by bioassay-guided fractionation from the culture broth of a bacterium,Bacillus sp., collected from a Pacific deep sea sediment sample (depth 5059 m). The structures of these compounds were determined using spectroscopic methods. Their cytotoxic effects on P388 and K562 cell lines were preliminarily examined using the sulforhodamine-B (SRB) assay.

Key words

Deep sea bacteria Bacillus sp Metabolite Antitumor activities 


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Copyright information

© The Pharmaceutical Society of Korea 2007

Authors and Affiliations

  1. 1.Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and FoodOcean University of ChinaQingdaoPR China
  2. 2.Key Laboratory of Marine Biogenetic Resources, Third Institute of OceanographyThe State Oceanic AdministrationXiamenP.R. China

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