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Norditerpenoid and dianthramide glucoside alkaloids from cultivatedaconitum species from Korea

  • So Young Lee
  • Sang Hee Shim
  • Ju Sun Kim
  • Je-Hyun Lee
  • Ho Young Lee
  • Da-Young Jung
  • Hyekyung Ha
  • Chungsook Kim
  • Sam Sik Kang
Article Drug Design

Abstract

A new norditerpene alkaloid named 8-O-methylhypaconine (1) was isolated along with twelve known alkaloids from the underground parts of an unknown species ofAconitum plant culti-vated in Korea. Among the known alkaloids, two dianthramide glucosides, N-(2′-β-glucopyra-nosyl-5′-hydroxysalicyl)-5-hydroxyanthranilic acid methyl ester (2) and N-(2′-β-glucopyranosyl-5′-hydroxysalicyl)-5-hydroxy-6-methoxyanthranilic acid methyl ester (3), were isolated fromAconitum plants for the first time. The structures were established on the basis of chemical and spectroscopic methods.

Key words

Aconitum species Ranunculaceae Norditerpenoid alkaloid Dianthramide glucoside 

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Copyright information

© The Pharmaceutical Society of Korea 2007

Authors and Affiliations

  • So Young Lee
    • 1
    • 4
  • Sang Hee Shim
    • 1
    • 5
  • Ju Sun Kim
    • 1
  • Je-Hyun Lee
    • 2
    • 6
  • Ho Young Lee
    • 3
  • Da-Young Jung
    • 3
  • Hyekyung Ha
    • 3
  • Chungsook Kim
    • 3
  • Sam Sik Kang
    • 1
  1. 1.Natural Products Research Institute and College of PharmacySeoul National UniversitySeoulKorea
  2. 2.Department of Oriental Pharmaceutical SciencesKyung Hee UniversitySeoulKorea
  3. 3.Department of Herbal Pharmaceutical DevelopmentKorea Institute of Oriental MedicineDaejeonKorea
  4. 4.Korea Research Institute of Bioscience and BiotechnologyDaejon
  5. 5.School of Biotechnology, Yeungnam UniversityGyeongsan
  6. 6.Dongguk UniversityGyeongjuKorea

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