Abstract
A new norditerpene alkaloid named 8-O-methylhypaconine (1) was isolated along with twelve known alkaloids from the underground parts of an unknown species ofAconitum plant culti-vated in Korea. Among the known alkaloids, two dianthramide glucosides, N-(2′-β-glucopyra-nosyl-5′-hydroxysalicyl)-5-hydroxyanthranilic acid methyl ester (2) and N-(2′-β-glucopyranosyl-5′-hydroxysalicyl)-5-hydroxy-6-methoxyanthranilic acid methyl ester (3), were isolated fromAconitum plants for the first time. The structures were established on the basis of chemical and spectroscopic methods.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Desai, H. K., Joshi, B. S., Ross, S. A., and Pelletier, S. W., Methanolysis of the C-8 Acetoxyl Group in Aconitine-Type Alkaloids: a Partial Synthesis of Hokbusine A.J. Nat. Prod., 52, 720–725 (1989).
Diaz, J. G., Marapara, J. L., Valdés, F., Sazatornil, J. G., and Herz, W., Dianthramide glucosides from tissue cell cultures ofDelphinium staphisagria L.Phytochemistry, 66, 733–739 (2005).
Hanuman, J. B. and Katz, A., Diterpenoid Alkaloids from Ayurvedic Processed and UnprocessedAconitum ferox.Phytochemistry, 36, 1527–1535 (1994a).
Hanuman, J. B. and Katz, A.,1H-NMR Spectra of Norditerpenoid Alkaloids. A Review.J. Nat. Prod., 57, 1473–1483 (1994b).
Katayama, H., Hasegawa, S., Sakai, S., Haginiwa, J., and Okamoto, T., On the Alkaloids ofAconitum japonicum THUNB. Collected at Mt. Mineoka (Chiba Pref.): Structure Elucidation and Partial Synthesis of a New Alkaloid, 15α-Hydroxyneoline.Yakagaku Zasshi, 102, 525–532 (1982).
Kim, Y. H., Hwang, B.Y., Kim, H. S., Lee, S. W., Lee, H. K., and Lee, J. J., Diterpenoid Alkaloid fromAconitum napiforme.Kor. J. Pharmacogn., 25, 395–398 (1994).
Konno, C., Shirasaka, M., and Hikino, H., Structure of Senbusine A, B and C, Diterpenic Alkaloids ofAconitum carmichaeli Roots from China.J. Nat. Prod., 45, 128–133 (1982).
Shim, S. H., Kim, J. S., and Kang, S. S., Norditerpenoid Alkaloids from the Processed Tubers ofAconitum carmichaeli.Chem. Pharm. Bull., 51, 999–1002 (2003a).
Shim, S. H., Kim, J. S., Kang, S. S., Son, K. H., and Bae K.-H., Alkaloidal Constituents fromAconitum jaluense.Arch. Pharm. Res., 26, 709–715 (2003b).
Shim, S. H., Lee, S. Y., Kim, J. S., Son, K. H., and Kang, S. S., Norditerpenoid Alkaloids and Other Components from the Processed Tubers ofAconitum carmichaeli.Arch. Pharm. Res., 28, 1239–1243 (2005).
Shim, S. H., Kim, J. S., Son, K. H., Bae, K.-H., and Kang, S. S., Alkaloids from the Roots ofAconitum pseudo-laeve var.erectum. J. Nat. Prod., 69, 400–402 (2006a).
Shim, S. H., Kim, J. S., Kang, S. S., Son, K. H., and Bae K.-H., A new Diterpenoid Alkaloid fromAconitum jaluense.J. Asian Nat. Prod. Res., 8, 451–455 (2006b).
Tang, W. and Eisenbrand, G., Chinese Drugs of Plant Origin, Springer-Verlag, Berlin, pp 19–44, (1992).
The Korean Herbal Pharmacopoeia, Korea Drug Test Laboratory, Seoul, p. 364, (2006).
The Korean Pharmacopoeia, 7th ed., MoonSung Co., Seoul, p 1057, (1998).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lee, S.Y., Shim, S.H., Kim, J.S. et al. Norditerpenoid and dianthramide glucoside alkaloids from cultivatedaconitum species from Korea. Arch Pharm Res 30, 691–694 (2007). https://doi.org/10.1007/BF02977629
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02977629