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Archives of Pharmacal Research

, Volume 30, Issue 3, pp 323–328 | Cite as

Effects of ß-glucan fromAureobasidium pullulans on acute inflammation in mice

  • Hyeong-Dong Kim
  • Hyung-Rae Cho
  • Seung-bae Moon
  • Hyun-Dong Shin
  • Kun-Ju Yang
  • Bok-ryeon Park
  • Hee-Jeong Jang
  • Lin-Su Kim
  • Hyeung-Sik Lee
  • Sae-Kwang Ku
Article

Abstract

The effects of ß-glucan isolated fromAureobasidium pullulans were observed on acute xylene-induced inflammation, ß-glucan at a dose of 62.5, 125 or 250 mg/kg were administered once orally to xylene-treated mice (0.03 mL of xylene was applied on the anterior surface of the right ear to induce inflammation), and the body weight change, ear weight, histological profiles and histomorphometrical analyses of ear were conducted upon sacrifice. The xylene was topically applied 30min after dosing with ß-glucan. The results were compared to those of diclofenac, indomethacin and dexamethasone (15 mg/kg injected once intraperitoneally). All animals were sacrificed 2 h after xylene application. Xylene application resulted in marked increases in induced ear weights compared to that of intact control ear; hence, the differences between intact and induced ear were also significantly increased. The histological characteristics of acute inflammation, such as severe vasodilation, edematous changes of skin and infiltration of inflammatory cells, were detected in xylene-treated control ears with marked increase in the thickness of the ear tissues. However, these xylene-induced acute inflammatory changes were significantly and dose-dependently decreased by ß-glucan treatment. We conclude that ß-glu-can fromA. pullulans has a somewhat favorable effect in the reduction of the acute inflammatory responses induced by xylene application in mice.

Key words

ß-Glucans Aureobasidium pullulans Acute inflammation Histology Mouse 

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Copyright information

© The Pharmaceutical Society of Korea 2007

Authors and Affiliations

  • Hyeong-Dong Kim
    • 4
  • Hyung-Rae Cho
    • 1
  • Seung-bae Moon
    • 1
  • Hyun-Dong Shin
    • 1
  • Kun-Ju Yang
    • 1
  • Bok-ryeon Park
    • 1
  • Hee-Jeong Jang
    • 1
  • Lin-Su Kim
    • 1
  • Hyeung-Sik Lee
    • 2
  • Sae-Kwang Ku
    • 3
  1. 1.Glucan Corp. Research Institute, Marine BiotechnologyBusan617-763Korea
  2. 2.Department of Herbal BiotechnologyDaegu Haany UniversityGyeongsanKorea
  3. 3.Pharmacology and Toxicology Laboratory, Central Research LaboratoriesDong- Wha Pharmaceutical Industrial Co, LtdAnyangKorea
  4. 4.Department of Physical Therapy, College of Health ScienceCatholic University of DaeguKorea

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