Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z2039-2
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Bioassay-guided fractionation of the EtOAc extract from the fermentation broth of a marine-derived actinomycete Z2039-2 led to the isolation of two known indolocarbazole alkaloids, K252c (1) and arcyriaflavin A (2).1 and2 exhibited moderate cytotoxic activities against the K562 cell line, and induced apoptotic activities at 10 and 100 μM, respectively. This is the first report on the significant apoptosis inducing effect of indolocarbazole alkaloids against K562 cancer cells.
Key wordsMarine-derived actinomycete Indolocarbazole alkaloids K252c Arcyriaflavin A Cytotoxicity Apoptosis inducer
- Kase, H., Iwahashi, K., Nakanishi, S., Matsuda, Y, Yamada, K., Takahashi, M., Murakata, C, Sato, A., and Kaneko. M., K- 252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases.,Biochem. Biophys. Res. Commum., 142, 436–440 (1987).CrossRefGoogle Scholar