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Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z2039-2

  • Rui Liu
  • Tianjiao Zhu
  • Dehai Li
  • Jingyan Gu
  • Wei Xia
  • Yuchun Fang
  • Hongbing Liu
  • Weiming Zhu
  • Qianqun Gu
Drug Design

Abstract

Bioassay-guided fractionation of the EtOAc extract from the fermentation broth of a marine-derived actinomycete Z2039-2 led to the isolation of two known indolocarbazole alkaloids, K252c (1) and arcyriaflavin A (2).1 and2 exhibited moderate cytotoxic activities against the K562 cell line, and induced apoptotic activities at 10 and 100 μM, respectively. This is the first report on the significant apoptosis inducing effect of indolocarbazole alkaloids against K562 cancer cells.

Key words

Marine-derived actinomycete Indolocarbazole alkaloids K252c Arcyriaflavin A Cytotoxicity Apoptosis inducer 

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Copyright information

© The Pharmaceutical Society of Korea 2007

Authors and Affiliations

  • Rui Liu
    • 1
  • Tianjiao Zhu
    • 1
  • Dehai Li
    • 1
  • Jingyan Gu
    • 1
  • Wei Xia
    • 1
  • Yuchun Fang
    • 1
  • Hongbing Liu
    • 1
  • Weiming Zhu
    • 1
  • Qianqun Gu
    • 1
  1. 1.Key laboratory of Marine Drugs, Chinese Ministry of Education; Institute of Marine Drugs and FoodOcean University of ChinaQingdaoPR China

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