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Archives of Pharmacal Research

, Volume 16, Issue 4, pp 322–326 | Cite as

Synthesis of 5-alkylthio (or sulfonyl)methyl-5-m-methoxyphenylhydantoin-3-acetic acid derivatives

  • Soon-kyoung Kwon
  • Myoung-suk Park
  • Young-ju Nam
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  • 16 Downloads

Abstract

For the development of new antiinflammatory and analgesic drugs, new 5-alkylthio (or sulfonyl) methyl-5-m-methoxyphenylhydantoin-3-acetic acid derivatives(alkyl; ethyl, propyl, butyl) were prepared. The 5,5-disubstituted hydantoins which were used as starting materials, were prepared according to Bucherer-Berg method. The reaction of ethyl chloroacetate with these compounds gave 3-acetate and the subsequent hydrolysis with dilute sodium hydroxide resulted in hydantoin 3-acetic acid derivatives. Through the same procedure of equivalent hydantoins or the oxidation of 5-alkylthiohydantoin compounds described above, 5-alkylsulfonylmethyl-5-m-methoxyphenylhydantoin-3-acetic acid derivatives were also synthesized.

Key words

5-Alkylthio (or sulfonyl) methyl-5-m-methoxyphenylhydantoin-3-acetic acid derivatives Antiinflammatory Analgesic 

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References Cited

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Copyright information

© The Pharmaceutical Society of Korea 1993

Authors and Affiliations

  • Soon-kyoung Kwon
    • 1
  • Myoung-suk Park
    • 1
  • Young-ju Nam
    • 1
  1. 1.College of PharmacyDuksung Women’s UniversitySeoulKorea

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