Archives of Pharmacal Research

, Volume 16, Issue 4, pp 283–288 | Cite as

Evaluation of some flavonoids as potential bradykinin antagonists

  • Hye Sook Yun-Choi
  • Sung Hyun Chung
  • Young Joo Kim
Research Article


Fourteen flavonoids were evaluated for their effects as potential bradykinin (BK) antagonists. The compounds were evaluated in severalin vitro andin vivo (oral administration) systems; inhibition of BK induced contractions in isolated rat ileum and uterus, antagonistic effects of BK induced plasma extravasation, reduction of acetic acid induced writhing nociception and protection from endotoxic shock. Skullcapflavone II (3), baicalein (5), 5-methoxyflavone (11), 6-methoxyflavone (12) and 2′-methoxyflavone (14) showed effects in all the tests although the order of potency were somewhat varied.

Key words

Potential bradykinin (BK) antagonists Skullcapflavone II Baicalein 5-Methoxyflavone 6-Methoxyflavone 2′-Methoxyflavone 


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Copyright information

© The Pharmaceutical Society of Korea 1993

Authors and Affiliations

  • Hye Sook Yun-Choi
    • 1
  • Sung Hyun Chung
    • 2
  • Young Joo Kim
    • 1
  1. 1.Natural Products Research InstituteSeoul National UniversitySeoulKorea
  2. 2.College of PharmacyKyung Hee UniversitySeoulKorea

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