Evaluation of some flavonoids as potential bradykinin antagonists
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Fourteen flavonoids were evaluated for their effects as potential bradykinin (BK) antagonists. The compounds were evaluated in severalin vitro andin vivo (oral administration) systems; inhibition of BK induced contractions in isolated rat ileum and uterus, antagonistic effects of BK induced plasma extravasation, reduction of acetic acid induced writhing nociception and protection from endotoxic shock. Skullcapflavone II (3), baicalein (5), 5-methoxyflavone (11), 6-methoxyflavone (12) and 2′-methoxyflavone (14) showed effects in all the tests although the order of potency were somewhat varied.
Key wordsPotential bradykinin (BK) antagonists Skullcapflavone II Baicalein 5-Methoxyflavone 6-Methoxyflavone 2′-Methoxyflavone
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