Abstract
The antinociceptive properties of the hydro-methanolic extract (HME) and two flavonoids isolated fromDanae racemosa have been investigated in several nociceptive rat models. The HME fromD. racemosa (100-400 mgkg-1, i.p.) produced significant dose-related inhibition of acetic acid-induced abdominal constriction. In the same dose range, the HME produced dose-related inhibition in both phases of a formalin-test. Treatment of animals with naloxone (5 mgkg-1, i.p.) completely reversed the antinociceptive effect caused by morphine (5 mgkg-1, s.c.) and the HME (200 mgkg-1, i.p.) when assessed against the first phase of the formalin-test, but this effect was less significant for the HME in the second phase. Furthermore, when assessed via a hot-plate test, the HME (100-400 mgkg-1, i.p.) caused a significant increase in response latency. The HME, given daily for to 7 consecutive days, develop tolerance, but did not induce cross-tolerance to morphine. These data demonstrate that the HME elicites pronounced anti-nociception against several pain models. The actions of the HME involve, at least in part, an interaction with the opioid system, but does not seem to be related with non-specific peripheral or central depressant actions. Finally, the active principle(s) responsible for the antinociceptive action ofD. racemosa is likely to be partially related to the presence of quercetin and kaempferol.
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Maleki-Dizaji, N., Fathiazad, F. & Garjani, A. Antinociceptive properties of extracts and two flavonoids isolated from leaves ofDanae racemosa . Arch Pharm Res 30, 1536–1542 (2007). https://doi.org/10.1007/BF02977322
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DOI: https://doi.org/10.1007/BF02977322