Acetylcholinesterase inhibitors from the roots ofangelica dahurica
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In the course of finding Korean natural products for acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the roots ofAngelica dahurica showed significant inhibitory effects on AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three furanocoumarins, isoimperatorin (1), imperatorin (2) and oxypeucedanin (3), as active principles. These compounds inhibited AChE activity in a dose-dependent manner, and the IC50 values of compounds1–3 were 74.6, 63.7 and 89.1 uM, respectively.
Key wordsAngelica dahurica Anticholinesterase activity Isoimperatorin Imperatorin Oxypeucedanin
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