Synthesis and antifungal activity of 6,7-bis-[s-(aryl)thio]-5,8-quinolinediones
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6,7-Bis-[S-(aryl)thio]-5,8-quinolinediones4 and5 were synthesized by the substitution of 6,7-dichloro-5,8-quinolinediones with appropriate arylthiols. Their antifungal activity were testedin vitro for their growth inhibitory activities against pathogenic fungi in comparison with flucytosine. The antifungal activities were significantly improved by S-(aryl)thio moieties of the compounds4 and5. The all tested compounds4 and5 showed generally good activities againstC. albicans andA. niger ranging from 0.8 to 25 μg/ml. Among them, compounds4d-4h and5a-5c exhibited also good activities againstC. krusei andC. tropicalis. The activities of compounds4j and41 were comparable to those of flucytosine against all tested fungi.
Key words6,7-Bis-[S-(aryl)thio]-5 8-quinolinediones Antifungal activity MIC minimum inhibitory concentration Candida species A. niger
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