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Synthesis and antifungal activity of 6,7-bis-[s-(aryl)thio]-5,8-quinolinediones

  • Chung -Kyu Ryu
  • Yang -Jung Sun
  • Ju -Yeon Shim
  • Hea -Jung You
  • Ko Un Choi
  • Heesoon Lee
Research Articles Article

Abstract

6,7-Bis-[S-(aryl)thio]-5,8-quinolinediones4 and5 were synthesized by the substitution of 6,7-dichloro-5,8-quinolinediones with appropriate arylthiols. Their antifungal activity were testedin vitro for their growth inhibitory activities against pathogenic fungi in comparison with flucytosine. The antifungal activities were significantly improved by S-(aryl)thio moieties of the compounds4 and5. The all tested compounds4 and5 showed generally good activities againstC. albicans andA. niger ranging from 0.8 to 25 μg/ml. Among them, compounds4d-4h and5a-5c exhibited also good activities againstC. krusei andC. tropicalis. The activities of compounds4j and41 were comparable to those of flucytosine against all tested fungi.

Key words

6,7-Bis-[S-(aryl)thio]-5 8-quinolinediones Antifungal activity MIC minimum inhibitory concentration Candida species A. niger 

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Copyright information

© The Pharmaceutical Society of Korea 2002

Authors and Affiliations

  • Chung -Kyu Ryu
    • 1
  • Yang -Jung Sun
    • 1
  • Ju -Yeon Shim
    • 1
  • Hea -Jung You
    • 1
  • Ko Un Choi
    • 1
  • Heesoon Lee
    • 2
  1. 1.College of PharmacyEwha Womans UniversitySeodaemun-kuKorea
  2. 2.College of PharmacyChungbuk National UniversityCheongjuKorea

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