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Archives of Pharmacal Research

, Volume 25, Issue 5, pp 640–642 | Cite as

Antiangiogenic activity ofBupleurum longiradiatum on human umbilical venous endothelial cells

  • Young-Jae You
  • Im-Seon Lee
  • Yong Kim
  • Ki-Hwan Bae
  • Byung-Zun Ahn
Research Articles Articles

Abstract

The ethyl acetate fraction ofBupleurum longiradiatum was found to have an inhibitory effect on the tube-like formation of human umbilical venous endothelial (HUVE) cells. The active compounds, isolated from the fraction, were identified as acetylbupleurotoxin (P1) and bupleurotoxin (P2). The compoundsP1 andP2 completely inhibited the tube-like formation of HUVE cells at 30 μg/ml, below the cytotoxic concentration. But, they did not exhibit antitumor activity on BDF1 mice bearing Lewis lung carcinoma cells despite their antiangiogenic activity.

Key words

Angiogenesis Bupleurum longiradiatum Acetylbupleurotoxin Bupleurotoxin 

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Copyright information

© The Pharmaceutical Society of Korea 2002

Authors and Affiliations

  • Young-Jae You
    • 1
  • Im-Seon Lee
    • 1
  • Yong Kim
    • 1
  • Ki-Hwan Bae
    • 1
  • Byung-Zun Ahn
    • 1
  1. 1.College of PharmacyChungnam National UniversityDaejeonKorea

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