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Archives of Pharmacal Research

, Volume 25, Issue 5, pp 600–607 | Cite as

Synthesis, cytotoxicity and antitumor activity of 2,3-Diarylcy-clopent-2-ene-1-ones

  • Nguyen-Hai Nam
  • Yong Kim
  • Young-Jae You
  • Dong-Ho Hong
  • Hwan-Mook Kim
  • Byung-Zun Ann
Research Articles Articles

Abstract

Two series of 2,3-diarylcyclopent-2-ene-1-ones including 2-aryl-3-(2,5-dihydroxyphenyl)cyclopent-2-ene-1-ones (2a~2f) and 3-aryl-2-(3′,4′,5′-trimethoxyphenyl)cyclopent-2-ene-1-one (3a~3j) were synthesized and evaluated for the cytotoxicity against three tumor cell lines; B16F10, HCT116 and A431. It was found that the 3,4,5-trimethoxy substituent was optimal for the bioactivity of compounds in series 2. Meanwhile, compounds in series3 exhibited the most potent cytotoxicity with 3-aryl ring being 4-methoxyphenyl (compound3f), (3-hydroxy-4-methoxy)phenyl (compound3e), or (3-amino-4-methoxy)phenyl (compound3j).

Key words

2,3-Diarylcyclopent-2-ene-1-ones Cytotoxicity Antitumor activity 

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References

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Copyright information

© The Pharmaceutical Society of Korea 2002

Authors and Affiliations

  • Nguyen-Hai Nam
    • 1
  • Yong Kim
    • 1
  • Young-Jae You
    • 1
  • Dong-Ho Hong
    • 1
    • 2
  • Hwan-Mook Kim
    • 2
  • Byung-Zun Ann
    • 1
  1. 1.College of PharmacyChungnam National UniversityDaejeonKorea
  2. 2.Research Institute of Biosciences and BiotechnologyDaejeonKorea

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