Archives of Pharmacal Research

, Volume 26, Issue 7, pp 521–525 | Cite as

A new sesquiterpene hydroperoxide from the aerial parts ofAster oharai

  • Sang Zin Choi
  • Sung Ok Lee
  • Sang Un Choi
  • Kang Ro Lee


Phytochemical works on the aerial parts ofAster oharai (Compositae) led to the isolation of a new sesquiterpene hydroperoxide, 7α-hydroperoxy-3, 11-eudesmadiene (2) and seven known compounds, teucdiol B (1), α-spinasterol (3), oleanolic acid (4), α-spinasterol 3-O-β-D-glucopyranoside (5), methyl 3,5-di-O-caffeoyl quinate (6), 3,5-di-O-caffeoylquinic acid (7), 3,4-di-O-caffeoylquinic acid (8). The chemical structures of1–8 were established by chemical and spectroscopic methods. Compound2 showed cytotoxicity against cultured human tumor cell linesin vitro, SK-OV-3 (ovarian), SK-MEL-2 (skin melanoma), and HCT15 (colon) with ED50 values ranging from 3.86-17.21 ug/mL.


Aster oharai Compositae Sesquiterpene hydroperoxide Quinic Acid Cytotoxicity 


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Copyright information

© The Pharmaceutical Society of Korea 2003

Authors and Affiliations

  • Sang Zin Choi
    • 1
  • Sung Ok Lee
    • 1
  • Sang Un Choi
    • 1
    • 2
  • Kang Ro Lee
    • 1
  1. 1.Natural Products Laboratory, College of PharmacySungKyunKwan UniversitySuwonKorea
  2. 2.Korea Research Institute of Chemical TechnologyTaejeonKorea

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