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Archives of Pharmacal Research

, Volume 26, Issue 6, pp 466–470 | Cite as

DNA topoisomerases I and II inhibitory activity of constituents isolated fromJuglans mandshurica

  • Gao Li
  • Sun -Young Lee
  • Kyeung -Seon Lee
  • Sung -Won Lee
  • Sang -Hyun Kim
  • Seung -Ho Lee
  • Chong -Soon Lee
  • Mi -Hee Woo
  • Jong -Keun Son
Article

Abstract

Nine diarylheptanoids (1–9), one triterpene (10), one sesquiterpenoid (11), one naphthoquinone (12), four tetralones (13–16), one naphthalene carboxylic acid glucoside (17) and six naphthalenyl glycosides (18–23) were isolated from the roots ofJuglans mandshurica Maxi-mowicz (Juglandaceae), and their structures determined from the chemical and spectral data. Here, we report the inhibitory effects, on the DNA topoisomerases I and II activities, of all these compounds. Compounds10 and23 showed more potent inhibitory effects, on the DNA topoisomerases I and II (94.0 and 86.0% inhibitions at the concentration of 5 (μg/mL, respectively), than the positive control compounds, camptothecin and etoposide.

Key words

Juglans mandshurica DNA topoisomerases I and II inhibitors 

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Copyright information

© The Pharmaceutical Society of Korea 2003

Authors and Affiliations

  • Gao Li
    • 1
  • Sun -Young Lee
    • 2
  • Kyeung -Seon Lee
    • 1
  • Sung -Won Lee
    • 1
  • Sang -Hyun Kim
    • 1
  • Seung -Ho Lee
    • 1
  • Chong -Soon Lee
    • 2
  • Mi -Hee Woo
    • 3
  • Jong -Keun Son
    • 1
  1. 1.College of PharmacyYeungnam UniversityGyongsanKorea
  2. 2.Department of Biochemistry, College of Natural SciencesYeungnam UniversityGyongsanKorea
  3. 3.College of PharmacyCatholic University of DaeguGyongsanKorea

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