DNA topoisomerases I and II inhibitory activity of constituents isolated fromJuglans mandshurica
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Nine diarylheptanoids (1–9), one triterpene (10), one sesquiterpenoid (11), one naphthoquinone (12), four tetralones (13–16), one naphthalene carboxylic acid glucoside (17) and six naphthalenyl glycosides (18–23) were isolated from the roots ofJuglans mandshurica Maxi-mowicz (Juglandaceae), and their structures determined from the chemical and spectral data. Here, we report the inhibitory effects, on the DNA topoisomerases I and II activities, of all these compounds. Compounds10 and23 showed more potent inhibitory effects, on the DNA topoisomerases I and II (94.0 and 86.0% inhibitions at the concentration of 5 (μg/mL, respectively), than the positive control compounds, camptothecin and etoposide.
Key wordsJuglans mandshurica DNA topoisomerases I and II inhibitors
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