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Archives of Pharmacal Research

, Volume 25, Issue 3, pp 240–249 | Cite as

2,3-Dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid γnes: structure and activity relationship in cytotoxic activity

  • Yong Kim
  • Young-Jae You
  • Nguyen-Hai Nam
  • Byung-Zun Ahn
Research Articles Articles

Abstract

Dibenzyl-g-butyrolactone and 1,2,3,4-tetrahydro-2-naphthoic acid γ(TNL) derivatives were synthesized and evaluated for cytotoxic activity against some cancer cell lines. It was found that TNL derivatives with a shorter distance between C-4 in ring A and C'-2 in ring C were more cytotoxic, while dibenzyl-γ-butyrolactones with a longer one were nearly inactive. In TNL series, presence of 3,4-dioxy group in ring A and 2-methoxy group in ring C was essential for the enhancement of the activity.

Key words

Yatein analogues Deoxypodophyllotoxin analogues Cytotoxic activity 

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Copyright information

© The Pharmaceutical Society of Korea 2002

Authors and Affiliations

  • Yong Kim
    • 1
  • Young-Jae You
    • 1
  • Nguyen-Hai Nam
    • 1
  • Byung-Zun Ahn
    • 1
  1. 1.College of PharmacyChungnam National UniversityDaejeonKorea

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