Abstract
Dibenzyl-g-butyrolactone and 1,2,3,4-tetrahydro-2-naphthoic acid γ(TNL) derivatives were synthesized and evaluated for cytotoxic activity against some cancer cell lines. It was found that TNL derivatives with a shorter distance between C-4 in ring A and C'-2 in ring C were more cytotoxic, while dibenzyl-γ-butyrolactones with a longer one were nearly inactive. In TNL series, presence of 3,4-dioxy group in ring A and 2-methoxy group in ring C was essential for the enhancement of the activity.
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Kim, Y., You, YJ., Nam, NH. et al. 2,3-Dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid γnes: structure and activity relationship in cytotoxic activity. Arch Pharm Res 25, 240–249 (2002). https://doi.org/10.1007/BF02976621
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DOI: https://doi.org/10.1007/BF02976621