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Archives of Pharmacal Research

, Volume 25, Issue 4, pp 441–445 | Cite as

Anti-human immunodeficiency virus-type 1 activity of constituents fromJuglans mandshurica

  • Byung Sun Min
  • Hyeong Kyu Lee
  • Sang Myung Lee
  • Young Ho Kim
  • Ki Hwan Bae
  • Toru Otake
  • Norio Nakamura
  • Masao Hattori
Research Articles Articles

Abstract

Three naphthalene glycosides (1-3), four flavonoids (4-7), and two galloyl glycosides (8-9) were isolated from the stem-bark ofJuglans mandshurica (Juglandaceae). Their structures were determined by chemical and spectral means, including to 2D-NMR (COSY, HMQC, and HMBC) experiments. Amongst the isolated compounds, taxifolin (4) showed the most potent HIV-induced cytopethic activity against MT-4 cells with complete inhibitory concentration (IC100) value of 25 μg/ml and maximum cytotoxic concentration (CC100) value of above 100 μg/ml. However, naphthalene glycosides (1-3), flavonoids (5-7)), and galloyl tannins (8-9) were inactive against anti-HIV-1 activity.

Key words

Juglans mandshurica Taxifolin Anti-HIV activity MT-4 cells 

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Copyright information

© The Pharmaceutical Society of Korea 2002

Authors and Affiliations

  • Byung Sun Min
    • 1
  • Hyeong Kyu Lee
    • 1
  • Sang Myung Lee
    • 1
  • Young Ho Kim
    • 2
  • Ki Hwan Bae
    • 2
  • Toru Otake
    • 3
  • Norio Nakamura
    • 4
  • Masao Hattori
    • 4
  1. 1.Immunomodulator Research LaboratoryKRIBBTaejonKorea
  2. 2.College of PharmacyChungnam National UniversityTaejonKorea
  3. 3.Osaka Prefectural Institute of Public healthOsakaJapan
  4. 4.Institute of Natural MedicineToyama Medical & Pharmaceutical UniversityToyamaJapan

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