Archives of Pharmacal Research

, Volume 24, Issue 2, pp 119–125 | Cite as

Toxicology ofKalopanax pictus extract and hematological effect of the isolated anti-rheumatoidal kalopanaxsaponin a on the freunds complete adjuvant reagent-treated rat

  • Jongwon Choi
  • Keun Huh
  • Suk-Hwan Kim
  • Kyung-Tae Lee
  • Sang-Hyuk Kwon
  • Hee-Juhn Park
Research Articles Pharmacology, Toxicology & Pharmaceutic


We have reported that kalopanaxsaponin A (KPS-A) isolated fromKalopanax pictus have antirheumatoidal activity in the rat treated with Freunds complete adjuvant (FCA) reagent. In addition, it has been also reported that KPS-A is a potent antioxidant in the rheumatoidal rat. This research was undertaken to examine whether the saponins of KPS-A and-I could adjust the abnormal lipid metabolisms and hematological changes in immunological diseases. KPS-A significantly inhibited the increases in both triglycerides and total proteins in addition to the decrease in total cholesterol induced by FCA reagent treatment. KPS-A treatment decreased the number of leucocytes elevated by FCA reagent treatment. Excess dose of the methanol extract produced no severe toxicity on the body weight, wet organ weights and hepatic functions. Since LD50 value ofK. pictus methanol extract was shown to be 4,033 mg/kg, it could be estimated to be a safe agent for anti-rheumatoidal herbal medicines.

Key words

Kalopanax pictus Kalopanaxsaponin A Freunds complete adjuvant toxicity hematology lipid metabolism 


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Copyright information

© The Pharmaceutical Society of Korea 2001

Authors and Affiliations

  • Jongwon Choi
    • 1
  • Keun Huh
    • 2
  • Suk-Hwan Kim
    • 3
  • Kyung-Tae Lee
    • 4
  • Sang-Hyuk Kwon
    • 5
  • Hee-Juhn Park
    • 5
  1. 1.College of PharmacyKyungsung UniversityPusanKorea
  2. 2.Korea Food and Drug AdministrationSeoulKorea
  3. 3.Department of Food Science and NutritionDong-A UniversityPusanKorea
  4. 4.College of PharmacyKyung-Hee UniversitySeoulKorea
  5. 5.Division of Applied Plant SciencesSangji UniversityWonjuKorea

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