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Aromatase inhibitors fromIsodon excisus var.coreanus

  • Hyeh-Jean Jeong
  • Leng Chee Chang
  • Ho-Kyoung Kim
  • Il-Hyuk Kim
  • A. Douglas Kinghorn
  • John M. Pezzuto
Research Articles Medicinal Chemistry & Natural Products

Abstract

The diethyl ether extract ofIsodon excisus var.coreanus exhibited significant inhibitory activity in aromatase assay. Bioactivity-guided fractionation of the extract led to the isolation of three active compounds: inflexin (ent-1α-hydroxy-3β,6a-diacetoxykaur-16-en-11,15-dione) (1), ursolic acid (2), and ursolic acid 3-O-acetate (3).

Key words

Aromatase inhibition Inflexin Ursolic acid 

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Copyright information

© The Pharmaceutical Society of Korea 2000

Authors and Affiliations

  • Hyeh-Jean Jeong
    • 1
  • Leng Chee Chang
    • 1
  • Ho-Kyoung Kim
    • 2
  • Il-Hyuk Kim
    • 2
  • A. Douglas Kinghorn
    • 1
  • John M. Pezzuto
    • 1
  1. 1.PCRPS and Department of Medicinal Chemistry and Pharmacognosy, College of PharmacyUniversity of Illinois at ChicagoChicagoU.S.A.
  2. 2.College of PharmacyChung-Ang UniversitySeoulKorea

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