Archives of Pharmacal Research

, Volume 19, Issue 5, pp 386–389 | Cite as

A novel ocular delivery system for phenylephrine hydrochloride

  • A. M. Durrani
  • M. Jamshaid
  • I. W. Kellaway
Research Articles


Thein vivo behaviour of phenylephrine hydrochloride in different vehicles like gels of Carbopol 907®, Carbopol 934P® and latex system of cellulose acetate hydrogen phthalate (CAHP) was evaluated by measuring the reduction in intraocular pressure and the mydriatic activity. The parameters that have been utilised to assess the performance of the formulations were the area under the curve (AUC), the maximum mydriasis (Imax), the time of maximum response (Tmax) and the duration of activity (D). The influence of viscosity and mucoadhesion on the bioavailability parameters has also been investigated. Carbopol 934P and CAHP formulations showed prolonged duration of action and greater AUC compared to Carbopol 907 and aqueous solution (P<0.05).

Key words

Carbopolr Cellulose acetate hydrogen phthalate (CAHP) Phenylephrine hydrochloride Mydriasis Intraocular pressure (I OP) Rabbit 


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References Cited

  1. Camber, O. and Edman, P., Sodium hyaluronate as an ophthalmic vehicle: some factors governing the effect of pilocarpine in rabbits, In: Camber O (ed).,Ocular Drug Delivery appendix. Uppsala University, Uppsala, Sweden, 1987, pp 44–50.Google Scholar
  2. Chen, J.L. and Cyr, G.N., Composition producing adhesion through hydration, in Adhesive Biological System. Manly, R.S. Ed., Academic Press, chap 10, New York, 1970.Google Scholar
  3. Chien, Y.W., Cabana, B.E. and Mares, S.E., Ocular controlled release drug administeration, In:Novel Drug Delivery Systems; Fundamentals, Developmental concepts, Biomedical Assessments. Drugs and the Pharmaceutical Sciences, Vol 14, Marcel Dekker, Inc., New York and Basel, 1982, pp. 13–50.Google Scholar
  4. Chrai., S.S. and Robinson, J.R., Ocular evaluation of methylcellulose vehicle in albino rabbits.J. Pharm. Sci., 63, 1218–1221 (1974).PubMedCrossRefGoogle Scholar
  5. Davies, N. M., Farr, S. J., Hadgraft, J. and Kellaway, I. W., The effect of mucoadhesive polymer on the bioavailability of pilocarpine.Proceed. Intern. Symp. Control Rel. Bioact. Mater., 15 (1988).Google Scholar
  6. Durrani, A. M., Farr, S. S. and Kellaway I. W., Precorneal clearance of mucoadhesive microspheres from the rabbit eye.J. Pharm. Pharmacol. 47, 581–584 (1995).PubMedGoogle Scholar
  7. Gurny, R., Ibrahim, H., Aebi, A., Buri, P., Wilson, C. G., Washington, N., Edman, P. and Camber, O., Design and evaluation of controlled release system for the eye.J. Controlled Release, 6, 367–373 (1987).CrossRefGoogle Scholar
  8. Gurny, R., Preliminary study of prolonged acting drug delivery system for the treatment of glaucoma.Pharmaceutica Acta Helv., 56, 131–132 (1981)Google Scholar
  9. Habib, F.S. and Attia, M.A., Comparative study of ocular activity in rabbit eyes of adrenaline bitartrate formulated in Carbopol® and poloxamer gels.Arch. Pharm. Chem. Ed., 12, 91–96 (1984).Google Scholar
  10. Park, K. and Robinson, J.R., Bioadhesive polymers as plateforms for oral controlled drug delivery; method to study bioadhesion.Int. J. Pharm., 19, 107–127 (1984)CrossRefGoogle Scholar
  11. Patton, T.F. and Robinson J.R. Ocular evaluation of polyvinyl alcohol in rabbits.J. Pharm. Sci., 64, 1312–1316 (1975).PubMedCrossRefGoogle Scholar
  12. Saettone, M.F., Monti D., Torracca, M.T., Chetoni, P. and Giannaccini, B., Mucoadhesive liquid ophthalmic vehicles Evaluation of macromoecular ionic complexes of pilocarpine.Drug. Dev. and Ind. Pharm., 15 (14–16), 2475–2489 (1989).CrossRefGoogle Scholar
  13. Schoenwald, R.D. and Smolen, V.F., Drug absorption analysis from pharmacological data. II: Transcorneal biophasic availability of tropicamide.J. Pharm. Sci., 60, 1039–1045 (1971).PubMedCrossRefGoogle Scholar
  14. Schoenwald, R. D., Ward, R. L., Desants, L. M. and Poehrs, R.E., Influence of high viscosity vehicles on the miotic effect of pilocarpine.J. Pharm. Sci., 67, 1280–1285 (1978).PubMedCrossRefGoogle Scholar
  15. Smart, J.D. Kellaway, I.W. and Worthington, H.E.C., Anin vitro investigation of mucoadhesive materials for use in controlled drug delivery.J. Pharm. Pharmacol., 36, 295–299 (1984).PubMedGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 1996

Authors and Affiliations

  • A. M. Durrani
    • 1
  • M. Jamshaid
    • 2
  • I. W. Kellaway
    • 3
  1. 1.Pharmacy DepartmentBalochistan UniversityQuettaPakistan
  2. 2.Faculty of PharmacyPunjab UniversityLahorePakistan
  3. 3.Welsh School of PharmacyUWCCardiffU.K.

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