Inhibitory activity of monoamine oxidase by coumarins fromPeucedanum japonicum
- 156 Downloads
Four coumarins were isolated from chloroform extract of the root ofPeucedanum japonicum and identified as praeruptorin A (1), xanthotoxin (2), psoralen (3) and bergapten (4) on the basis of spectroscopic methods. The inhibitory activities of these coumarins on monoamine oxidase prepared by mouse brain were tested. The IC50 values of them were shown to be 27.4 μM (1), 40.7 μM (2), 35.8 μM (3), and 13.8 μM (4),in vitro.
Key wordsPeucedanum japonicum Umbelliferae Coumarins Monoamine oxidase
Unable to display preview. Download preview PDF.
- Choi, H. C., Rho, T. C., Kim, B. Y., Ko, H. R., Seung, C. K., Ahn, J. S. and Lee, H. S., Inhibition of nitric oxide production by coumarins fromPeucedanum japonicum in LPS-activated RAW 264.7 cells.Kor. J. Pharmacogn. submitted (1999).Google Scholar
- Kraml, M., A rapid microfluorometric determination of monoamine oxidase.Biochem. Pharmacol., 14, 1683–1685, 1965.Google Scholar
- Perry, L. M.,Medicinal plants of east and southeast Asia. The MIT Press, Massachusetts, 1980.Google Scholar