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Archives of Pharmacal Research

, Volume 22, Issue 3, pp 324–326 | Cite as

Inhibitory activity of monoamine oxidase by coumarins fromPeucedanum japonicum

  • Dang Thi Lan Huong
  • Hee Cheol Choi
  • Tae Cheol Rho
  • Hyun Sun Lee
  • Myung Koo Lee
  • Young Ho Kim
Note

Abstract

Four coumarins were isolated from chloroform extract of the root ofPeucedanum japonicum and identified as praeruptorin A (1), xanthotoxin (2), psoralen (3) and bergapten (4) on the basis of spectroscopic methods. The inhibitory activities of these coumarins on monoamine oxidase prepared by mouse brain were tested. The IC50 values of them were shown to be 27.4 μM (1), 40.7 μM (2), 35.8 μM (3), and 13.8 μM (4),in vitro.

Key words

Peucedanum japonicum Umbelliferae Coumarins Monoamine oxidase 

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Copyright information

© The Pharmaceutical Society of Korea 1999

Authors and Affiliations

  • Dang Thi Lan Huong
    • 1
  • Hee Cheol Choi
    • 2
  • Tae Cheol Rho
    • 2
  • Hyun Sun Lee
    • 2
  • Myung Koo Lee
    • 3
  • Young Ho Kim
    • 1
  1. 1.College of PharmacyChungnam National UniversityTaejonKorea
  2. 2.Korea Research Institute of Bioscience and Biotechnology (KRIBB)TaejonKorea
  3. 3.College of PharmacyChungbuk National UniversityCheongjuKorea

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