Inhibition of aromatase activity by flavonoids
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In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC50: 0.9 μg/mL), chrysin (IC50: 1.1 μg/mL), and hesperetin (IC50: 1.0 μg/mL).
Key wordsAromatase inhibition Flavonoids Breast cancer
- Rabe, T., Rabe, D. and Punnebaum, B.: New aromatase assay and its application for inhibitory studies of aminogluthetimide on microsomes of human term placenta.J. Steroid Biochem., 7, 305–309 (1982).Google Scholar