Inhibition of aromatase activity by flavonoids
- 381 Downloads
In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC50: 0.9 μg/mL), chrysin (IC50: 1.1 μg/mL), and hesperetin (IC50: 1.0 μg/mL).
Key wordsAromatase inhibition Flavonoids Breast cancer
- Rabe, T., Rabe, D. and Punnebaum, B.: New aromatase assay and its application for inhibitory studies of aminogluthetimide on microsomes of human term placenta.J. Steroid Biochem., 7, 305–309 (1982).Google Scholar