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Archives of Pharmacal Research

, Volume 18, Issue 6, pp 458–461 | Cite as

Biotransformation of dehydroparadols byAspergillus niger

  • Sang-Sup Lee
  • Woo-Young Lee
Research Articles

Abstract

To prove uniqueness of allylic alcohol formation from α,β-unsaturated ketones by mammal enzymes, a metabolic pattern of dehydroparadols, non-pungent synthetic analogs of shogaol byAspergillus niger was examined. Two biotransformation products of a dehydroparadol, 1-(4-hydroxy-3-methoxyphenyl)-non-1-en-3-one were accumulated in the culture broth ofA. niger. They were characterized as 1-(4-hydroxy-3-methoxyphenyl)-non-1-en-9-ol-3-one and 1-(4-hydroxy-3-methoxyphenyl)-nonan-9-ol-3-one by UV, NMR and mass spectroscopic analyses. Accumulation of allylic alcohol metabolites was not observed.

Key words

Dehydroparadol ω-Hydroxyparadol ω-Hydroxydehydroparadol Metabolic pattern of dehydroparadol Aspergillus niger Biotransformation 

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Copyright information

© The Pharmaceutical Society of Korea 1995

Authors and Affiliations

  • Sang-Sup Lee
    • 1
  • Woo-Young Lee
    • 2
  1. 1.College of PharmacySeoul National UniversitySeoulKorea
  2. 2.Pharmaceutical ResearchPacific CorporationYonginKorea

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