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Archives of Pharmacal Research

, Volume 27, Issue 12, pp 1290–1294 | Cite as

Determination of stability constants of the inclusion complexes of β-blockers in heptakis (2,3-dimethyl-6-sulfato)-β-cyclodextrin

  • Nuyen Thi Phuong
  • Kyung Ah Lee
  • Kyung Ho Kim
  • Jung Kap Choi
  • Jong Moon Kim
  • Jong Seong Kang
Research Article Article

Abstract

The β-blockers possess at least one chiral center and the S(-)-enantiomer shows higher affinity for binding to the β-adrenergic receptors than antipode. The stability constants of acebutolol, celiprolol, propranolol and terbutaline in the inclusion complexes with single-isomer heptakis (2,3-dimethyl-6-sulfato)-β-cyclodextrin (HDMS-β-CD) were determined by capillary electrophoresis. The approximation and linear double reciprocal methods were adapted with comparable results. Among the β-blockers studied, propranolol had the lowest stability constant but the highest enantioselectivity, indicating that the magnitudes of the stability constants carried little information about enantioseparation. The magnitudes of enantioselectivities between the enantiomer pair were in the order of propranolol > celiprolol > terbutaline > acebutolol.

Key words

Stability constant β-Blockers Heptakis (2,3-dimethyl-6-sulfato)-β-cyclodextrin Capillary electrophoresis 

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Copyright information

© The Pharmaceutical Society of Korea 2004

Authors and Affiliations

  • Nuyen Thi Phuong
    • 1
  • Kyung Ah Lee
    • 1
  • Kyung Ho Kim
    • 2
  • Jung Kap Choi
    • 3
  • Jong Moon Kim
    • 4
  • Jong Seong Kang
    • 1
  1. 1.College of PharmacyChungnam National UniversityDaejeonKorea
  2. 2.College of PharmacyKangwon National UniversityChunchonKorea
  3. 3.College of PharmacyChonnam National UniversityKwangjuKorea
  4. 4.Central Research InstituteIlsung Pharmaceutical Co.Kyunggi-doKorea

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