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Archives of Pharmacal Research

, Volume 23, Issue 4, pp 302–309 | Cite as

Synthesis of (−)-neplanocin A analogues as potential antiviral agents

  • Dae Hong Shin
  • Hyuk Woo Lee
  • Sung Soo Park
  • Joong Hyup Kim
  • Lak Shin Jeong
  • Moon Woo Chun
Research Articles Medicinal Chemistry & Natural Products

Abstract

Based on (-)-neplanocin A with the 5’-hydroxyl substituted with fluoro, azido, or amino group, the corresponding xylo-and arabino derivatives were synthesized from D-ribose using the Mitsunobu reaction as a key step. None of the final nucleosides did show either significant antiviral activities or cytotoxicities.

Key words

Neplanocin A Nucleosides Antiviral activity Cytotoxicity S-adenosylhomocysteine hydrolase 

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References

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Copyright information

© The Pharmaceutical Society of Korea 1999

Authors and Affiliations

  • Dae Hong Shin
    • 1
  • Hyuk Woo Lee
    • 1
  • Sung Soo Park
    • 1
  • Joong Hyup Kim
    • 2
  • Lak Shin Jeong
    • 3
  • Moon Woo Chun
    • 1
  1. 1.College of PharmacySeoul National UniversitySeoulKorea
  2. 2.Korea Institute of Science and TechnologySeoulKorea
  3. 3.College of PharmacyEwha Womans UniversitySeoulKorea

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