Synthesis of (−)-neplanocin A analogues as potential antiviral agents
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Based on (-)-neplanocin A with the 5’-hydroxyl substituted with fluoro, azido, or amino group, the corresponding xylo-and arabino derivatives were synthesized from D-ribose using the Mitsunobu reaction as a key step. None of the final nucleosides did show either significant antiviral activities or cytotoxicities.
Key wordsNeplanocin A Nucleosides Antiviral activity Cytotoxicity S-adenosylhomocysteine hydrolase
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