Archives of Pharmacal Research

, Volume 21, Issue 5, pp 549–554 | Cite as

Changes of tissue factor activity on inflammatory stimulus and aging in rat

  • Yong Nam Han
  • In Kyung Rhee
Research Articles


Tissue factor (TF), a principal initiator of the vertebrate coagulation cascade, is expressed in organ tissues, cells and blood. TF is known to be induced in endothelial cells, monocytes and macrophages by inflammatory stimuli and in many pathologic conditions. By using the modified method forin vivo TF activity assay, we found that turpentine oil injection as an inflammatory stimulus also induced the TF activity in lung and brain tissues of rats. And the age-related increase in TF activity was observed in healthy rat brain tissue.

Key words

Brain tissue factor Lung tissue factor Inflammatory stimulus Age-related increase of tissue factor 


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Copyright information

© The Pharmaceutical Society of Korea 1998

Authors and Affiliations

  • Yong Nam Han
    • 1
  • In Kyung Rhee
    • 1
  1. 1.Natural Products Research InstituteSeoul National UniversitySeoulKorea

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