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Immunobioloical activity of a new benzyl benzoate from the aerial parts ofSolidago virga-aurea var.gigantea

  • Sang Zin Choi
  • Sang Un Choi
  • Seong Yun Bae
  • Suhk neung Pyo
  • Kang Ro Lee
Article Drug design

Abstract

The chromatographic separation of the hexane soluble fraction of the methanol extract of the aerial parts ofSolidago virga-aurea var.gigantea MIQ. (Compositae) led to the isolation of a new benzylbenzoate (1) together with four known benzylbenzoates (2~5). Their structures were determined as 2-methoxybenzyl-2-hydroxybenzoate (1), benzyl-2-hydroxy-6-methoxy-benzoate (2), 2-methoxybenzyl-2,6-dimethoxybenzoate (3), 2-methoxybenzyl-2-methoxy-6-hydroxybenzoate (4), and benzyl-2,6-dimethoxybenzoate (5). Their structures were established by spectroscopic methods. Biological effects of compounds,1 and2, were investigatedin vitro using mouse peritoneal macrophages. The benzylbenzoates (1 and2) could serve as immunotherapeutic agents by stimulating macrophage functions, with potential use in the treatment of infectious diseases.

Key words

Solidago virga-aurea var.gigantea MIQ Compositae Benzyl benzoates Macrophage 

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Copyright information

© The Pharmaceutical Society of Korea 2005

Authors and Affiliations

  • Sang Zin Choi
    • 1
  • Sang Un Choi
    • 1
    • 2
  • Seong Yun Bae
    • 1
    • 3
  • Suhk neung Pyo
    • 1
    • 3
  • Kang Ro Lee
    • 1
  1. 1.Natural Products Laboratory, College of PharmacySungKyunKwan UniversityJangan-ku, Suwon, Kyunggi-DoKorea
  2. 2.Korea Research Institute of Chemical TechnologyTaejeonKorea
  3. 3.Division of Immunopharmacology College of PharmacySungKyunKwan UniversitySuwon, Kyunggi-DoKorea

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