Abstract
Seven diterpenes, four polyacetylenes, a lipid glycerol, and two sterols were isolated from the methylene chloride fraction of the root ofAralia cordata. Their chemical structures were determined as (-)-pimara-8(14),15-dien-19-oic acid (2), pimaric acid (3), (-)-kaur-16-en-19-oic acid (4), 17-hydroxy-ent-kaur-15-en-19-oic acid (9), 7α-hydroxy-(-)-pimara-8(14),15-dien-19-oic acid (10), 16α, 17-dihydroxy-(-)-kauran-19-oic acid (11), 16-hydroxy-17-isovaleroyloxy-ent-kauran-19-oic acid (12), falcarindiol (5), dehydrofalcarindiol (6), dehydrofalcarindiol-8-acetate (7), falcarindiol-8-acetate (8), alpha-mono palmitin (13), stigmasterol (1), and daucosterol (14) by the spectral evidences. These compounds were tested with COX-1 and COX-2 inhibition assays. This study found that compounds2, 4, 5, 6, 7, 8, and10 inhibited COX-1 dependent conversion of the exogenous arachidonic acid to PGE2 in a dose-dependent manner with IC50 values of 134.2 μM, 121.6 μM, 170 μM, 50.4 μM, 11.7 μM, 99.6 μM, and 69.6 μM, respectively. But, most of these compounds weakly inhibited COX-2 dependent PGE2 generation. Among them, only compound 4 showed relatively significant inhibitory activity (IC50: 127.6 μM).
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Dang, N.H., Zhang, X., Zheng, M. et al. Inhibitory Constituents against Cyclooxygenases fromAralia cordata Thunb. Arch Pharm Res 28, 28–33 (2005). https://doi.org/10.1007/BF02975131
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DOI: https://doi.org/10.1007/BF02975131