Anti-Diabetic activities of fucosterol fromPelvetia siliquosa
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Fucosterol isolated fromPelvetia siliquosa was tested for its anti-diabetic activityin vivo. Fucosterol, when administered orally at 30 mg/kg in streptozotocin-induced diabetic rats, was caused a significant decrease in serum glucose concentrations, and exhibited an inhibition of sorbitol accumulations in the lenses. Fucosterol, when administered orally at 300 mg/kg in epinephrine-induced diabetic rats, was also caused an inhibition of blood glucose level and glycogen degradation. These results demonstrated that fucosterol is a main anti-diabetic principle from the marine algaeP. siliquosa.
Key wordsPelvetia siliquosa Fucaceae Fucosterol Anti-diabetic activity
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- Drabkin, D. S. and Ausin, J. H., Spectrophotometric constants for common hemoglobin derivatives in human, dog, and rabbit blood.J. Biol. Chem., 98, 719 (1932).Google Scholar
- Lee, Y. S., Jung, S. H., Lee, S., Choi, Y. J., and Shin, K. H., Hepatoprotective and anti-diabetic effects ofPelvetia siliquosa, a marine algae, in rats.J. Appl. Pharmacol., 10, 165–169 (2002).Google Scholar
- Mariam, A., Asmawi, M. Z., and Sadikun., Hypoglycemic activity of the aqueous extract ofOrthosiphon stamineus.Fitoterapia, 57, 465–468 (1996).Google Scholar
- Oh, Y. S., Lee, I. K., and Boo, S. M., An annotated account of Korean economic seaweeds for food, medical and industrial uses.Kor. J. Phycol., 5, 57–71 (1990).Google Scholar
- Trinder, P. Determination of glucose using glucose oxidase with an alternative oxygen acceptor.Ann. Clin. Biochem., 6, 24–27 (1969).Google Scholar
- Yoon, J. T., Developmental morphology on the regeneration ofPelvetia siliquosa Tseng et Chang, Phaeophyta in Korea. Chonbuk National University. Ph. D. Thesis (1995).Google Scholar