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Archives of Pharmacal Research

, Volume 27, Issue 11, pp 1120–1122 | Cite as

Anti-Diabetic activities of fucosterol fromPelvetia siliquosa

  • Yeon Sil Lee
  • Kuk Hyun Shin
  • Bak-Kwang Kim
  • Sanghyun Lee
Research Article Article

Abstract

Fucosterol isolated fromPelvetia siliquosa was tested for its anti-diabetic activityin vivo. Fucosterol, when administered orally at 30 mg/kg in streptozotocin-induced diabetic rats, was caused a significant decrease in serum glucose concentrations, and exhibited an inhibition of sorbitol accumulations in the lenses. Fucosterol, when administered orally at 300 mg/kg in epinephrine-induced diabetic rats, was also caused an inhibition of blood glucose level and glycogen degradation. These results demonstrated that fucosterol is a main anti-diabetic principle from the marine algaeP. siliquosa.

Key words

Pelvetia siliquosa Fucaceae Fucosterol Anti-diabetic activity 

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Copyright information

© The Pharmaceutical Society of Korea 2004

Authors and Affiliations

  • Yeon Sil Lee
    • 2
  • Kuk Hyun Shin
    • 2
  • Bak-Kwang Kim
    • 1
    • 2
  • Sanghyun Lee
    • 1
    • 2
  1. 1.College of PharmacySeoul National UniversitySeoulKorea
  2. 2.Seokwon Life Science Research InstituteWorld Sea Green Co. Ltd.PajuKorea

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