Abstract
Objective: To detect the existence of immune tolerance induced by gamma-ray irradiation. Methods: Peritoneal cells were harvested from mice subjected to 5 Gy60Co gamma-ray total body irradiation at 3d, 7d, 15d and 30d, then their counts, morphological changes and IL-12 gene expression were investigated. Results: After irradiation, the peritoneal cells were sharply reduced, the cell morphology shifted from round-like to polymorphic and fusiform with some processes, expression of IL-12 p35 was seriously suppressed, while that of IL-12 p40 greatly enhanced. Conclusion: Our data highly suggest that the gamma-ray irradiation could potentially induce dendritic cell (DC) commitment and immune tolerance.
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Foundation item: This work was supported by the National Natural Science Foundation of China(No. 39670289) and by a grant from Ministry of Education of China.
Biography: LIAN Yan(1972-), female, bachelor of science, Southwest Hospital, Third Military Medical University, majors in immune therapy. E-mail: Iianyan98@yahoo.com
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Lian, Y., Wang, Yj., Su, Yp. et al. Immune tolerance induced by gamma-ray irradiation. Chin J Cancer Res 15, 121–123 (2003). https://doi.org/10.1007/BF02974914
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DOI: https://doi.org/10.1007/BF02974914