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Chinese Journal of Cancer Research

, Volume 15, Issue 2, pp 121–123 | Cite as

Immune tolerance induced by gamma-ray irradiation

  • Lian Yan 
  • Wang Yan-jiang 
  • Su Yong-ping 
  • Ran Xin-ze 
  • Ai Guo-ping 
  • Liu Xiao-hong 
  • Guo Chao-hua 
  • Cheng Tian-min 
Article
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Abstract

Objective: To detect the existence of immune tolerance induced by gamma-ray irradiation. Methods: Peritoneal cells were harvested from mice subjected to 5 Gy60Co gamma-ray total body irradiation at 3d, 7d, 15d and 30d, then their counts, morphological changes and IL-12 gene expression were investigated. Results: After irradiation, the peritoneal cells were sharply reduced, the cell morphology shifted from round-like to polymorphic and fusiform with some processes, expression of IL-12 p35 was seriously suppressed, while that of IL-12 p40 greatly enhanced. Conclusion: Our data highly suggest that the gamma-ray irradiation could potentially induce dendritic cell (DC) commitment and immune tolerance.

Key words

Peritoneal lavage cell Dendritic cell Immune tolerance Irradiation Interleukin 12 Morphology 

CLC number

R730.51 

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Copyright information

© Chinese Journal of Cancer Research 2003

Authors and Affiliations

  • Lian Yan 
    • 1
  • Wang Yan-jiang 
    • 2
  • Su Yong-ping 
    • 2
  • Ran Xin-ze 
    • 2
  • Ai Guo-ping 
    • 2
  • Liu Xiao-hong 
    • 2
  • Guo Chao-hua 
    • 2
  • Cheng Tian-min 
    • 2
  1. 1.Department of Hematology & OncologySouthwest HospitalChongqing
  2. 2.Institute of Combined InjuryThird Military Medical UniversityChongqing

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