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Chinese Journal of Cancer Research

, Volume 9, Issue 2, pp 79–82 | Cite as

Influence of alpha-fetoprotein on the growth of tumor cellsin vitro

  • Wang Xingwang 
  • Xu Bin 
Basic Investigations
  • 11 Downloads

Abstract

It has been recognized that alpha-fetoprotein (AFP), as an oncofetal antigen, re-expresses in large amounts in adult tumor cells and serves clinically useful purposes as a tumor marker assay. However, its biological activities are still far from clear. In the present study, the ability of AFP to stimulate tumor cell growth was observed byin vitro test system. The new finding indicates that AFP contributes to the generation and development of tumor and is an important target action site of tumor therapy.

Key words

Alpha-fetoprotein Liver neoplasma Animal model In vitro experiment 

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References

  1. 1.
    1997; 490.Google Scholar
  2. 2.
    Gershwin ME, Castles JJ, Makishima R. Acelerated plasmacytoma formation in mice treated with alpha-fetoprotein. J National Cancer Inst 1980; 64:145.Google Scholar
  3. 3.
    Yamada A, Hayami M. Suppression of natural killer cell activity by chicken alpha-fetoprotein in Japanese quails. J National Cancer Inst 1983; 70:735.Google Scholar
  4. 4.
    1991; 11:111.Google Scholar
  5. 5.
    Wang XW, Xu B. Anti-alpha-fetoprotein activity of L-4-oxalysine. Asia Pacific J Pharmacol 1996; 11:25.Google Scholar
  6. 6.
    Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival: modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986; 89:271.PubMedCrossRefGoogle Scholar
  7. 7.
    Gorin MB, Cooper DL, Eiferman F, et al. The evolution of alpha-fetoprotein and albumin I. A comparison of the primary amino acid sequences of mammalian alpha-fetoprotein and albumin. J Biol Chem 1981; 256: 1954.PubMedGoogle Scholar
  8. 8.
    1995; 4:24.Google Scholar

Copyright information

© Chinese Journal of Cancer Research 1997

Authors and Affiliations

  • Wang Xingwang 
    • 1
  • Xu Bin 
    • 1
  1. 1.Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai

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