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Archives of Pharmacal Research

, Volume 21, Issue 4, pp 370–373 | Cite as

Studies on the effects of piperidine derivatives on blood pressure and smooth muscles contractions

  • M. Saeed
  • Z. S. Saify
  • A. H. Gilani
  • Z. Iqbal
Research Articles

Abstract

Ten substituted phenacyl derivatives of 4-hydroxypiperidine were synthesized and studied for their effects on the mean arterial blood pressure (MABP) in normotensive anaesthetized rats and smooth muscles contractions of isolated rabbit jejunum. Two derivatives caused fall in blood pressure at the dose of 10≈20 mg/kg and one rise in blood pressure at the dose of 20 mg/kg. Two compounds exhibited biphasic response (hypotensive followed by hypertensive) and one gave triphasic response at 10 mg/kg dose. Rest of four derivatives were found devoid of any effect on mean arterial blood pressure up to the dose of 30 mg/kg. All the derivatives except two caused relaxant effect on the spontaneous contraction of rabbit jejunum at the dose range of 0.1≈2 mg/kg.

Key words

Piperidine Antihypertensive Smooth muscle contraction 

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Copyright information

© The Pharmaceutical Society of Korea 1998

Authors and Affiliations

  • M. Saeed
    • 1
  • Z. S. Saify
    • 2
  • A. H. Gilani
    • 3
  • Z. Iqbal
    • 1
  1. 1.Department of PharmacyUniversity of PeshawarPeshawarPakistan
  2. 2.Department of Pharmaceutical Chemistry, Faculty of PharmacyUniversity of KarachiKarachiPakistan
  3. 3.Department of PharmacologyAga Khan Medical UniversityKarachiPakistan

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