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Archives of Pharmacal Research

, Volume 16, Issue 3, pp 254–256 | Cite as

Recognition of pharmacophore of ar-turmerone for its anticancer activity

  • Kyong-Up Baik
  • Sang-Hun Jung
  • Byung-Zun Ahn
Notes

Abstract

For the evaluation of the role of α,β-unsaturated ketone portion of ar-turmerone for its activity, the structural variation of this structural unit was performed to omit its alkylating property. Thus compounds2, 3, and4 were prepared and their cytotoxicities were determined against three different leukemia cell lines (HL-60, K-562, and L1210)in vitro. The biological inactivity against three different cell lines of these analogues implies that the α,β-unsaturated ketone of ar-turmerone is the essential pharmacophore for its activity.

Key words

Pharmacophore ar-Turmerone Cytotoxicity Anticancer activity 

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Copyright information

© The Pharmaceutical Society of Korea 1993

Authors and Affiliations

  • Kyong-Up Baik
    • 1
  • Sang-Hun Jung
    • 1
  • Byung-Zun Ahn
    • 1
  1. 1.College of PharmacyChung-Nam National UniversityTaejonKorea

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