Recognition of pharmacophore of ar-turmerone for its anticancer activity
- 59 Downloads
For the evaluation of the role of α,β-unsaturated ketone portion of ar-turmerone for its activity, the structural variation of this structural unit was performed to omit its alkylating property. Thus compounds2, 3, and4 were prepared and their cytotoxicities were determined against three different leukemia cell lines (HL-60, K-562, and L1210)in vitro. The biological inactivity against three different cell lines of these analogues implies that the α,β-unsaturated ketone of ar-turmerone is the essential pharmacophore for its activity.
Key wordsPharmacophore ar-Turmerone Cytotoxicity Anticancer activity
Unable to display preview. Download preview PDF.
- Ahn, B. Z. and Lee, J. H., Cytotoxic and cytotoxicity-potentiating effects of the curcuma root on L1210 cell.Korean J. Pharmacognosy, 20, 223–226 (1989).Google Scholar
- Lee, J. H., Kang, S. K., and Ahn, B. Z., Antineoplastic natural products and the analogues(XI)-Cytotoxic activity against L1210 cell of some raw drugs from the oriental medicine and falklore.Korean J. Pharmacognosy, 17, 286–291 (1986).Google Scholar
- Perrin, D. D. and Armarego, W. L. F.,Purification of Laboratory Chemicals, 3rd Edition, Pergamon, Oxford, 1988, pp. 65–309.Google Scholar
- Thayer, P. S., Himmerlfarb, P. and Watts, G. L., Cytotoxicity assay with L1210 cellin vitro, Comparison with L1210 in vitro and KB cellsin vitro.Cancer Chem. Rep., 2, 1–25 (1971).Google Scholar