Archives of Pharmacal Research

, Volume 29, Issue 2, pp 178–182 | Cite as

Crystal form of cephradine

  • Young Taek Sohn
  • Sun Hee Park
Articles Drug Efficacy


Four crystal forms of cephradine were isolated by recrystallization and characterized by powder X-ray diffractometry, differential scanning calorimetry, and thermogravimetric analysis. The dissolution patterns of four crystal forms of cephradine were studied in water at 37±0.5°C, 90 rpm for 120 min. The amount dissolved at 120 min was highest for Form I (100%), followed by Form 3 (98.9%), Form 4 (77.83%), and Form 2 (75.55%). After storage for two months at 0% RH (silica gel, 20°C), 52% RH (saturated solution of Na2Cr2O7·2H2O/20°C), and 95% RH (saturated solution of Na2HPO4/20°C), none of the crystal forms showed transformation.

Key words

Cephradine Crystal form Polymorphism Solubility Transformation 


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Copyright information

© The Pharmaceutical Society of Korea 2006

Authors and Affiliations

  1. 1.College of PharmacyDuksung Women’s UniversitySeoulKorea

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