Synthesis and quartermization of 6-(substitutedamino)-purines with antitumor activity screening
Reaction of 6-chloro-9-benzyl-8-(methylthio)purine3 with primary amines afforded, the corresponding 6-(substitutedamino)purines4a-g. The latter products when methylated with methyl iodide yielded smoothly N3-methyl purinium iodide salts5a-f rather than the probable N1-and N7-derivatives. 9-Benzyl-3-methyl-6-(methylimino)-8-(methylthio)purine8 was obtained upon treating the purinium iodide5a with alkali. Most of the synthesized compounds were screened for their antitumor activity.
Key wordsSubstifutedamino-purines Quartemization Antitumor activity
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