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Archives of Pharmacal Research

, Volume 17, Issue 2, pp 60–65 | Cite as

Synthesis and quartermization of 6-(substitutedamino)-purines with antitumor activity screening

  • Khairy A. M. El-Bayouki
  • Wahid M. Basyouni
  • S. M. El-Din
  • A. G. Habeeb
Research Articles

Abstract

Reaction of 6-chloro-9-benzyl-8-(methylthio)purine3 with primary amines afforded, the corresponding 6-(substitutedamino)purines4a-g. The latter products when methylated with methyl iodide yielded smoothly N3-methyl purinium iodide salts5a-f rather than the probable N1-and N7-derivatives. 9-Benzyl-3-methyl-6-(methylimino)-8-(methylthio)purine8 was obtained upon treating the purinium iodide5a with alkali. Most of the synthesized compounds were screened for their antitumor activity.

Key words

Substifutedamino-purines Quartemization Antitumor activity 

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Copyright information

© The Pharmaceutical Society of Korea 1994

Authors and Affiliations

  • Khairy A. M. El-Bayouki
    • 1
  • Wahid M. Basyouni
    • 1
  • S. M. El-Din
    • 1
  • A. G. Habeeb
    • 1
  1. 1.National Research CenterCairoEgypt

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