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Effects of barbiturates on the rotational relaxation time of 1,6-diphenyl-1,3,5-hexatriene in native and model membranes

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Abstract

Synaptosomal plasma membrane vesicles (SPMV) were isolated from fresh bovine cerebral cortex. The effects of barbiturates on the rotational relaxation time of 1,6-diphenyl-1,3,5-hexatriene (DPH) in intact SPMV and model membranes of total lipids (SPMVTL) and phospholipids (SPMVPL) extracted from SPMV were examined. Barbiturates decreased the rotational relaxation time of DPH in intact SPMV in a dose-dependent manner. In contrast, they did not affect the rotational relaxation time of DPH in SPMVTL and even dose-dependently increased the rotational relaxation time of DPH in SPMVPL.

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Authors and Affiliations

  1. Department of Biochemistry, College of Pharmacy, Kyungsung University, 608-736, Pusan, Korea

    Yong-Za Chung

  2. Department of Pharmaceutics, College of Pharmacy, Kyungsung University, 608-736, Pusan, Korea

    Yong-Hee Shin

  3. Department of Neurosurgery, College of Medicine, Pusan National University, 602-739, Pusan, Korea

    Chang-Hwa Choi

  4. Department of Fundamental Nursing, College of Medicine, Pusan National University, 602-739, Pusan, Korea

    Hyung-Sook Park

  5. Department of Chemistry College of Natural Sciences, Pusan National University, 609-735, Pusan, Korea

    Yeong-Sim Koh

  6. Department of Dental Pharmacology and Biophysics, College of Dentistry, Pusan National University, 602-739, Pusan, Korea

    Il Yun

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  1. Yong-Za Chung
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Chung, YZ., Shin, YH., Choi, CH. et al. Effects of barbiturates on the rotational relaxation time of 1,6-diphenyl-1,3,5-hexatriene in native and model membranes. Arch. Pharm. Res. 15, 298–303 (1992). https://doi.org/10.1007/BF02974102

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  • DOI: https://doi.org/10.1007/BF02974102

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