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Archives of Pharmacal Research

, Volume 15, Issue 4, pp 298–303 | Cite as

Effects of barbiturates on the rotational relaxation time of 1,6-diphenyl-1,3,5-hexatriene in native and model membranes

  • Yong-Za Chung
  • Yong-Hee Shin
  • Chang-Hwa Choi
  • Hyung-Sook Park
  • Yeong-Sim Koh
  • Il Yun
Original Articles
  • 16 Downloads

Abstract

Synaptosomal plasma membrane vesicles (SPMV) were isolated from fresh bovine cerebral cortex. The effects of barbiturates on the rotational relaxation time of 1,6-diphenyl-1,3,5-hexatriene (DPH) in intact SPMV and model membranes of total lipids (SPMVTL) and phospholipids (SPMVPL) extracted from SPMV were examined. Barbiturates decreased the rotational relaxation time of DPH in intact SPMV in a dose-dependent manner. In contrast, they did not affect the rotational relaxation time of DPH in SPMVTL and even dose-dependently increased the rotational relaxation time of DPH in SPMVPL.

Keywords

Barbiturates native and model membranes fluidity fluorescent probe technique 

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Copyright information

© The Pharmaceutical Society of Korea 1992

Authors and Affiliations

  • Yong-Za Chung
    • 1
  • Yong-Hee Shin
    • 2
  • Chang-Hwa Choi
    • 3
  • Hyung-Sook Park
    • 4
  • Yeong-Sim Koh
    • 5
  • Il Yun
    • 6
  1. 1.Department of Biochemistry, College of PharmacyKyungsung UniversityPusanKorea
  2. 2.Department of Pharmaceutics, College of PharmacyKyungsung UniversityPusanKorea
  3. 3.Department of Neurosurgery, College of MedicinePusan National UniversityPusanKorea
  4. 4.Department of Fundamental Nursing, College of MedicinePusan National UniversityPusanKorea
  5. 5.Department of Chemistry College of Natural SciencesPusan National UniversityPusanKorea
  6. 6.Department of Dental Pharmacology and Biophysics, College of DentistryPusan National UniversityPusanKorea

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