Archives of Pharmacal Research

, 29:741 | Cite as

Estrogenic activity of furanocoumarins isolated fromAngelica dahurica

  • Xiang Lan Piao
  • Hye Hyun Yoo
  • Hyun Young Kim
  • Tak Lim Kang
  • Gwi Seo Hwang
  • Jeong Hill Park
Articles Drug Development


In our efforts to discover novel phytoestrogens to treat menopausal symptoms, eleven furanocoumarins were isolated fromAngelica dahurica and tested for their estrogenic activity on the Ishikawa cell line. Among the compounds tested, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin showed strong abilities to induce alkaline phosphatase (AP) with EC50 values of 1.1 and 0.8 μg/mL, respectively, whereas the other nine furanocoumarins were weakly or only slightly active.

Key words

Angelica dahurica Umbelliferae Furanocoumarin Estrogenic activity 


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Copyright information

© The Pharmaceutical Society of Korea 2006

Authors and Affiliations

  • Xiang Lan Piao
    • 1
  • Hye Hyun Yoo
    • 2
  • Hyun Young Kim
    • 3
  • Tak Lim Kang
    • 4
  • Gwi Seo Hwang
    • 5
  • Jeong Hill Park
    • 3
  1. 1.School of Pharmaceutical SciencesPeking UniversityBeijingChina
  2. 2.Bioanalysis and Biotransformation Research CenterKorea Institute of Science and TechnologySeoulKorea
  3. 3.Research Institute of Pharmaceutical Sciences, College of PharmacySeoul National UniversitySeoulKorea
  4. 4.College of Oriental MedincineTaejon UniversityTaejonKorea
  5. 5.College of Oriental MedicineKyungwon UniversityGyeonggi-DoKorea

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