Relative bioavailability studies on two tablet preparations of ofloxacin
- 26 Downloads
Comparative bioavailability of two tablet dosage forms of ofloxacin (either as Hoechst (India) or Ranbaxy preparation) was investigated. In a randomized cross-over study, eight healthy human volunteers received single 200 mg dose of film coated ofloxacin in fasting state. The concentrations of ofloxacin in the collected saliva and serum samples were measured by high performance liquid chromatography. No significant difference in bioavailability of both preparations was judged from various serum and saliva pharmacokinetic parameters such as peak concentration, time to peak concentration and area under the curves. Intersubject variation was also found to be insignificant.
KeywordsOfloxacin comparative bioavailability
Unable to display preview. Download preview PDF.
- 2.Kalager, T., Digranes, A., Bergan, T. and Rolstad, T.:Pharmacokinetics of of ofloxacin in serum and skin blister. In: Proceedings of the 14th, International Congress on Chemotheraphy, Kyoto, pp. 1765–66 (1985).Google Scholar
- 6.Uematsu, M., Morihana, T., Sekiguchi, T., Imoto, T. and Sasaki, J.: The pharmacokinetics and saliva penetration of ofloxacin, norfloxacin, enoxacin and pipemidic acid. In. Proceedings of 14th International Congress on Chemotherapy, Kyoto, pp. 1891–92 (1985).Google Scholar