Archives of Pharmacal Research

, Volume 15, Issue 3, pp 208–210 | Cite as

Relative bioavailability studies on two tablet preparations of ofloxacin

  • Ashok K. Shakya
  • Naresh Talwar
  • Jayant Karajgi
  • Akhlesh Singhai
Original Articles


Comparative bioavailability of two tablet dosage forms of ofloxacin (either as Hoechst (India) or Ranbaxy preparation) was investigated. In a randomized cross-over study, eight healthy human volunteers received single 200 mg dose of film coated ofloxacin in fasting state. The concentrations of ofloxacin in the collected saliva and serum samples were measured by high performance liquid chromatography. No significant difference in bioavailability of both preparations was judged from various serum and saliva pharmacokinetic parameters such as peak concentration, time to peak concentration and area under the curves. Intersubject variation was also found to be insignificant.


Ofloxacin comparative bioavailability 


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Literature Cited

  1. 1.
    Wittenberger R.:Ofloxacin versus pipemidsaure und cotrimoxazole. Infection14 (Suppl. 1), 93 (1986).CrossRefGoogle Scholar
  2. 2.
    Kalager, T., Digranes, A., Bergan, T. and Rolstad, T.:Pharmacokinetics of of ofloxacin in serum and skin blister. In: Proceedings of the 14th, International Congress on Chemotheraphy, Kyoto, pp. 1765–66 (1985).Google Scholar
  3. 3.
    Okhamafe, A. O and Akerele, J. O.:Some aspects of the bioavailability of orally administered ofloxacin in healthy human volunteers.Int. J. Pharm.,50, 83 (1989).CrossRefGoogle Scholar
  4. 4.
    Greenblatt, D. J., Smith, T. W. and Koch-wester, J.,Bioavailability of drugs: the digoxin dilemma.Clin. Pharmacokin.1, 36 (1976).CrossRefGoogle Scholar
  5. 5.
    Chan, C. Y., Lam, A. W. and French, G. L.:Rapid HPLC assay of fluoroquinolones in clinical specimens.Antimicrob. Chemother.23, 597 (1989).CrossRefGoogle Scholar
  6. 6.
    Uematsu, M., Morihana, T., Sekiguchi, T., Imoto, T. and Sasaki, J.: The pharmacokinetics and saliva penetration of ofloxacin, norfloxacin, enoxacin and pipemidic acid. In. Proceedings of 14th International Congress on Chemotherapy, Kyoto, pp. 1891–92 (1985).Google Scholar

Copyright information

© The Pharmaceutical Society of Korea 1992

Authors and Affiliations

  • Ashok K. Shakya
  • Naresh Talwar
  • Jayant Karajgi
  • Akhlesh Singhai

There are no affiliations available

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