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Archives of Pharmacal Research

, Volume 20, Issue 1, pp 80–84 | Cite as

Synthesis of substituted cinnamoyl-tyramine derivatives and their platelet anti-aggregatory activities

  • Nam-Tae Woo
  • Sun Yong Jin
  • Dae Jin Cho
  • Nam Sun Kim
  • Eun Hyung Bae
  • Ducky Han
  • Byung Hoon Han
  • Young-Hwa Kang
Research Articles

Abstract

Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-coupling of substituted cinnamic acid with tyramine or tyramine methyl-1-ether to evaluate PAF-receptor binding antagonistic activities and inhibitory activities on PAF-induced platelet aggregation with interest on structure-activity relations. The results show that 3,4-dimethoxy-cinnamoyl tyramine-amide or its methyl ether have significant PAF-receptor binding antagonistic activity and platelet anti-aggregatory activities.

Key words

Platelet anti-aggregatory activities PAF-receptor binding antagonistic activity Substituted cinnamoyl tyramine amides 

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References cited

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Copyright information

© The Pharmaceutical Society of Korea 1997

Authors and Affiliations

  • Nam-Tae Woo
    • 1
  • Sun Yong Jin
    • 1
  • Dae Jin Cho
    • 1
  • Nam Sun Kim
    • 1
  • Eun Hyung Bae
    • 1
  • Ducky Han
    • 1
  • Byung Hoon Han
    • 2
  • Young-Hwa Kang
    • 2
  1. 1.Il-Yang Central Research InstituteKyungkiKorea
  2. 2.Natural Product Research InstituteSeoul National UniversitySeoulKorea

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