Synthesis of substituted cinnamoyl-tyramine derivatives and their platelet anti-aggregatory activities
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Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-coupling of substituted cinnamic acid with tyramine or tyramine methyl-1-ether to evaluate PAF-receptor binding antagonistic activities and inhibitory activities on PAF-induced platelet aggregation with interest on structure-activity relations. The results show that 3,4-dimethoxy-cinnamoyl tyramine-amide or its methyl ether have significant PAF-receptor binding antagonistic activity and platelet anti-aggregatory activities.
Key wordsPlatelet anti-aggregatory activities PAF-receptor binding antagonistic activity Substituted cinnamoyl tyramine amides
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