Archives of Pharmacal Research

, Volume 15, Issue 1, pp 20–29 | Cite as

Effects of squalene on the immune responses in mice(II): Cellular and non-specific immune response and antitumor activity of squalene

  • Young Keun Ahn
  • Joung Hoon Kim
Original Articles


Effects of squalene on cellular and non-specific immune responses and antitumor activity in mice were investigated. Cellular and non-specific immunological assay parameters adopted in the present study were delayed-type hypersensitivity reaction and rosette forming cells (RFC) for cellular immunity, activities of natural killer (NK) cells and phagocyte for non-specific immunity. Squalene resulted in marked increases of cellular and non-specific immune functions and enhancement of host resistance to tumor challenge in dose-dependent manner.


Squalene delayed-type hypersensitivity reaction rosette forming cell natural killer cell activity phagocytic activity host resistance to tumor challenge 


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Copyright information

© The Pharmaceutical Society of Korea 1992

Authors and Affiliations

  • Young Keun Ahn
    • 1
  • Joung Hoon Kim
    • 1
  1. 1.College of PharmacyWon Kwang UniversityIriKorea

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