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Archives of Pharmacal Research

, Volume 29, Issue 10, pp 879–883 | Cite as

Trials of novel13C-urea-containing capsule for more economic and sensitive diagnosis ofHelicobacter pylori infection in human subjects

  • Chul Soon Yong
  • Yong-II Kim
  • San-Man Park
  • Rham Kwon
  • Hong-Hee Han
  • Jung Gil Park
  • Chan-Yoo Yang
  • Jung-Ae Kim
  • Bong-Kyu Yoo
  • Jong-Dal Rhee
  • Han-Gon Choi
Articles Drug Development

Abstract

To develop a13C-urea-containing capsule for more economic and sensitive diagnosis ofHelicobacter pylori infection, the13C-urea-containing capsules were prepared with various additives such as polyethylene glycol, microcrystalline cellulose, sodium lauryl sulfate and citric acid. Their dissolution test and13C-urea Breath Test in human volunteers were then performed. Polyethylene glycol increased the initial dissolution rates of urea and difference δ13C values from13C-urea, while microcrystalline cellulose and sodium lauryl sulfate decreased them. Irrespective of addition of citric acid, the compositions with polyethylene glycol showed higher values from13C-urea compared to a commercial 76 mg13C-urea-containing capsule due to higher initial dissolution rate. The capsules with 38 mg13C-urea and 1.9 mg polyethylene glycol, which showed higherHelicobacter pylori-positive value of about 8%. at 10 min, improved the sensitivity of13C-urea in human volunteers. Thus, the13C-urea-containing capsule with polyethylene glycol would be a more economical and sensitive preparation for diagnosis ofHelicobacter pylori infection.

Key words

Helicobacter pylori Urea Polyethylene glycol Dissolution 13C-Urea breath test 

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Copyright information

© The Pharmaceutical Society of Korea 2006

Authors and Affiliations

  • Chul Soon Yong
    • 1
  • Yong-II Kim
    • 1
  • San-Man Park
    • 1
  • Rham Kwon
    • 1
  • Hong-Hee Han
    • 1
  • Jung Gil Park
    • 1
  • Chan-Yoo Yang
    • 1
  • Jung-Ae Kim
    • 1
  • Bong-Kyu Yoo
    • 1
  • Jong-Dal Rhee
    • 1
  • Han-Gon Choi
    • 1
  1. 1.College of PharmacyYeungnam UniversityGyongsanKorea

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