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A new monoterpene glycoside and antibacterial monoterpene glycosides fromPaeonia suffruticosa

  • Ren-Bo An
  • Hyun-Chul Kim
  • Sung-Hee Lee
  • Gil-Saeng Jeong
  • Dong-Hwan Sohn
  • Hyun Park
  • Dong-Yeul Kwon
  • John Hwa Lee
  • Youn-Chul Kim
Articles Drug Design

Abstract

Antibacterial activity-guided fractionation of the CHCl3−MeOH (1∶1) extract ofPaeonia suffruticosa root bark furnished three monoterpene glycosides, 6-O-vanillyoxypaeoniflorin (1), mudanpioside-H (2), and galloyl-oxypaeoniflorin (3). Of the isolated compounds, compound1 is a new compound. All isolated compounds showed broad, but moderate, antibacterial activity with minimum inhibitory concentration (MIC) values in the range of 100 to 500 μg/mL against eighteen pathogenic microorganisms of concern for public health or zoonosis.

Key words

Paeonia suffruticosa 6-O-Vanillyoxypaeoniflorin Monoterpene glycoside mudanpioside-H Galloyl-oxypaeoniflorin Antibacterial 

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Copyright information

© The Pharmaceutical Society of Korea 2006

Authors and Affiliations

  • Ren-Bo An
    • 1
    • 2
  • Hyun-Chul Kim
    • 1
  • Sung-Hee Lee
    • 1
  • Gil-Saeng Jeong
    • 1
  • Dong-Hwan Sohn
    • 1
  • Hyun Park
    • 3
  • Dong-Yeul Kwon
    • 1
  • John Hwa Lee
    • 4
  • Youn-Chul Kim
    • 1
  1. 1.College of PharmacyWonkwang UniversityIksanKorea
  2. 2.College of PharmacyYanbian UniversityYanji, JilinChina
  3. 3.Department of Infection Biology, College of MedicineWonkwang UniversityIksanKorea
  4. 4.College of Veterinary Medicine and Bio-Safety Research InstituteChonbuk National UniversityChonjuKorea

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