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Archives of Pharmacal Research

, Volume 28, Issue 8, pp 902–908 | Cite as

Prevention of arthritic inflammation using an oriental herbal combination BDX-1 isolated fromAchyranthes bidentata andAtractylodes japonica

  • Sang-Bae Han
  • Chang Woo Lee
  • Leo Dae Yoon
  • Jong-Ho Lee
  • Jong Soon Kang
  • Ki Hoon Lee
  • Won Kee Yoon
  • Kiho Lee
  • Song-Kyu Park
  • Hwan Mook Kim
Articles Drug Development

Abstract

An oriental herbal combination (BDX-1) was isolated fromAchyranthes bidentata andAtractylodes japonica. We previously tested the clinical effectiveness of BDX-1 in rheumatoid arthritis (RA) patients and found that it has a beneficial therapeutic effect. Here, we provide experimental evidence for the effectiveness of BDX-1 on RA in murine models. The oral administration of BDX-1 was found to markedly inhibit collagen-induced arthritis, adjuvant-induced arthritis, and zymosan-induced inflammation. It also inhibited carrageenan-induced acute edema and acetic acid-induced writhing response. In addition, the biological activity of BDX-1 was found to be strongly increased by fermentation. Our results suggest that BDX-1 could be useful for the treatment of rheumatoid arthritis.

Key words

BDX-1 Atractylodes japonica Achyranthes bidentata Rheumatoid arthritis 

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Copyright information

© The Pharmaceutical Society of Korea 2005

Authors and Affiliations

  • Sang-Bae Han
    • 1
  • Chang Woo Lee
    • 1
  • Leo Dae Yoon
    • 1
  • Jong-Ho Lee
    • 2
  • Jong Soon Kang
    • 1
  • Ki Hoon Lee
    • 1
  • Won Kee Yoon
    • 1
  • Kiho Lee
    • 1
  • Song-Kyu Park
    • 1
  • Hwan Mook Kim
    • 1
  1. 1.Korea Research Institute of Bioscience and Biotechnology (KRIBB)TaejonKorea
  2. 2.BIORADIX Co., LtdKyunggiKorea

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