Advertisement

Archives of Pharmacal Research

, Volume 28, Issue 10, pp 1111–1113 | Cite as

Synthesis of 5-aminolevulinic acid (ALA) and itst-butyl ester for the fluorescence detection of early cancer

  • Min-Seok Kang
  • Dong-Myung Kim
  • Jeong Sook Kim
  • Jin-Hyun Jeong
Articles Drug Design

Abstract

5-Aminolevulinic acid and its derivatives, which are known to affect the early diagnosis and treatment of cancer, have been synthesized. Simple methods for the synthesis of 5-aminolevulinic acid (ALA), a precursor of porphyrins, have been developed in our laboratory for use in studies on the biosynthesis of porphyrins.

Key words

5-Aminolevulinic acid Fluorescence detection ALA PDT 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Andreas, P. and Saeed, A., Synthesis of-aminoketones via selective reduction of cyanides.Tetrahedron Lett., 25, 2977–2980 (1984).CrossRefGoogle Scholar
  2. Cortese, D. A., Pairolero, P. C., Bergstrath, E. J., Woolner, L. B., Uhlenhopp, M. A., Piehler, J. M., Sanderson, D. R., Bernatz, P. E., Williams, D. E., Taylor, W. F., Payne, W. S., and Fontana, R. S., Roentgenographically occult lung cancer.J. Thorac. Cardiovasc. Surgery, 86, 373–380 (1983).Google Scholar
  3. Fontana, R. S., Sanderson, D. R., Woolner, L. B., Taylor, W. F., Miller, W. E., Muhm, J. R., Bernatz, P. E., Payne, W. S., Pairolero, P. C., and Bergstalh, E. J., Screening for lung cancer.Cancer, 67, 1155–1164 (1991).PubMedCrossRefGoogle Scholar
  4. Katsumi, I. and Masahiro, K., Synthesis of13C- and15N-multilabeled 5-aminolevulinic acid.J. Label Compd. Radiopharm., 45, 139–143 (2002).CrossRefGoogle Scholar
  5. Robert, W. W. and Alsoph, H. C., The hydrogenation of oxaloacetone. A new synthesis of thioimidazolylpropionic acid, Contribution from the chemical laboratories of the Johns Hopkins Univ.Google Scholar
  6. Rudolf, M. H., Gamarra, F., Hautmann, H., Haubinger, K., Wagner, S., Castro, M., and Baumgartner, R., 5-Aminolevulinic acid for the fluorosence detection of bronchial tumors.Diagnosis and Therapeutic Endoscopy, 5, 113–118 (1999).CrossRefGoogle Scholar
  7. Yoshihisa, N., Tamami, N., Masataka, A., Kazuyoshi, Y., Masakazu, Y., and Hiroshi, T., Enhanced photodynamic antitumor effect on gastric cancer by a novel photosensitive stealth liposome.Pharmacol. Res., 50, 65–76 (2004).CrossRefGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 2005

Authors and Affiliations

  • Min-Seok Kang
    • 2
  • Dong-Myung Kim
    • 2
  • Jeong Sook Kim
    • 1
  • Jin-Hyun Jeong
    • 2
  1. 1.PDT Bio Co. LtdKyung Hee UniversitySeoulKorea
  2. 2.College of PharmacyKyung Hee UniversitySeoulKorea

Personalised recommendations