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Gastropathie atrophique: dépistage de masse et surveillance des sujets «à risque élevé»

Atrophic gastritis: mass screening and follow-up of high — Risk subjects

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Acta Endoscopica

Résumé

Compte tenu du rôle deprécancérose joué par la gastropathie atrophique et de la valeur élevée de son incidence chez les individus entre les 40 et les 60 ans, les auteurs ont voulu rapporter les résultats d'un dépistage de masse effectué chez les proteurs de cette affection et de l'organisation d'un programme de follow-up, plus particulièrement des patients porteurs de gastropathie atrophique avec métaplasie intestinale, situation définie à risque élevé.

C'est dans ce but que l'on a utilisé tout premièrement la détermination de la gastrinémie basale, à laquelle on a fait suivre, en présence de valeurs supérieurs aux valeurs normales, le gastroacidogramme basal et après stimulation par histamine et la gastroscopie avec biopsies multiples pour examen histologique, immunologique et enzymologique.

Plus particulièrement, la détermination des isoenzymes de la lactatedéshydrogénase (LDH) s'est révélée très valable pour dépister, à un stade initial, la transformation maligne d'une gastropathie atrophique avec métaplasie intestinale à un degré élevé.

Summary

Considering the role of precancerosis played by atrophic gastritis and the high value of its incidence in people in the 40 to 60 age group, the authors wished to report the results of a mass screening undertaken on carriers of this affection and of the organisation of a follow-up programme and especially of patients carrying atrophic gastritis with intestinal metaplasia, a defined high-risk situation.

It is to this end that the determination of the fasting serum gastrin was first of all used. This was followed in presence of greater values than as normal, by basal gastroacidogram and after histamine stimulation and gastroscopy with multiple biopsies for a histological, immunological and enzymological examination.

The determination of lactatodehydrogenas, more especially, showed itself very valid in screening, at an initial stage, the malignant transformation of an atrophic gastritis with a high degree of intestinal metaplasia.

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Authors and Affiliations

  1. Institut de Clinique Médicale III de l'Université de Milan, via Marozzo della Rocca 1, 20123, Milano, Italia

    A. Tittobello, P. A. Testoni, A. Evangelista, G. Ronchi, L. Bierti, M. Cambielli, M. Guslandi, E. Fesce & Daniela Grimoldi

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  1. A. Tittobello
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  2. P. A. Testoni
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  3. A. Evangelista
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  4. G. Ronchi
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  5. L. Bierti
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  6. M. Cambielli
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  7. M. Guslandi
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  8. E. Fesce
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  9. Daniela Grimoldi
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Tittobello, A., Testoni, P.A., Evangelista, A. et al. Gastropathie atrophique: dépistage de masse et surveillance des sujets «à risque élevé». Acta Endosc 8, 111–122 (1978). https://doi.org/10.1007/BF02970280

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  • DOI: https://doi.org/10.1007/BF02970280

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