P63 expression in normal, hyperplastic and malignant breast tissues
- 207 Downloads
p63 is a homologue of the p53 tumor suppressor gene and its protein is selectively expressed in the basal cells of a variety of epithelial tissues. It has recently been confirmed that p63 is expressed in the basal cells of normal prostate glands but not in prostatic carcinomas. Whether expression of p63 in breast correlates with tumor progression is the focus of this study.
Forty cases, which all contained normal breast tissue, ductal hyperplasia, ductal carcinomain situ and invasive ductal carcinoma in the same patient were included in this investigation using an indirect immunohistochemical method and double staining.
p63 was exclusively expressed in the myoepithelial cells of normal breast, partially expressed in ductal hyperplasia, rarely expressed in carcinomain situ and not expressed in invasive carcinomas.
The results suggest an association between loss of p63 expression and progression of breast ductal carcinoma. p63 immunostaining might be of assistance for distinguishing invasive ductal carcinoma from ductal carcinomain situ or rare questionable ductal hyperplastic lesions, leading to correct therapy clinically.
Key wordsp63 Ductal intraepithelial neoplasia Intraductal hyperplasia Atypical ductal hyperplasia Ductal carcinomain situ Breast cancer Immunohistochemistry
Ductal carcinomain situ
Smooth muscle actin
Unable to display preview. Download preview PDF.
- 5).Trink B, Okami K, Wu L,et al: A new human p53 homologue.Nat Med 248: 603–607, 1998.Google Scholar
- 11).Osborne MP: Breast anatomy and development. In: Harris, Jay R eds, Diseases of the Breast, 2nd ed, Lippincott Williams & Wilkins, Philadelphia, p9, 2000.Google Scholar
- 14).Yang A, McKeon F, Wang Y,et al: p63 and p73: p53 mimics, menaces and more.Nature Rev Mol Cell Biol 1: 194–207, 2000.Google Scholar
- 15).Gottlieb C, Raju U, Greenwald KA: Myoepithelial cells in the differential diagnosis of complex benign and malignant breast lesions: an Immunohistochemical study.Mod Pathol 3: 134–140, 1990.Google Scholar