Breast Cancer

, 9:20 | Cite as

Breast-conserving treatment after neoadjuvant chemotherapy in large breast cancer

  • Hideo Inaji
  • Yoshifumi Komoike
  • Kazuyoshi Motomura
  • Tsutomu Kasugai
  • Yuka Sawai
  • Masahiko Koizumi
  • Takayuki Nose
  • Hiroki Koyama
Review Article


Several recent trials have demonstrated that neoadjuvant chemotherapy can allow more patients to successfully undergo breast-conserving treatment (BCT), and does not confer a survival disadvantage compared with standard adjuvant chemotherapy. In addition, the pathological response of primary breast tumors to neoadjuvant chemotherapy appears to be a surrogate marker for patient outcome.

In our series, during the period from May 1995 to December 2000, 86 patients with tumors between 3.1 and 6.0 cm in diameter received epirubicin-based neoadjuvant chemotherapy. There were 55 (64.0%) responders and ultimately 64 patients (74.4%) were treated with BCT. The margin positive rate was 14.1% (9/64), similar to the rate after BCT for early-stage breast cancers, the largest diameter of which was smaller than 3 cm. At a median follow-up of 30 months, only 3 patients in the BCT group have developed local recurrence; the local recurrence rate appears to be comparable to that after BCT for early stage breast cancers. Long term follow-up is required, however, to establish whether this procedure is a safe alternative to mastectomy for patients with large breast cancers.

Key words

Breast cancer Neoadjuvant chemotherapy Breast-conserving treatment Local recurrence 


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Copyright information

© The Japanese Breast Cancer Society 2002

Authors and Affiliations

  • Hideo Inaji
    • 1
  • Yoshifumi Komoike
    • 1
  • Kazuyoshi Motomura
    • 1
  • Tsutomu Kasugai
    • 2
  • Yuka Sawai
    • 3
  • Masahiko Koizumi
    • 4
  • Takayuki Nose
    • 4
  • Hiroki Koyama
    • 1
  1. 1.Departments of SurgeryOsaka Medical Center for Cancer and Cardiovascular DiseasesJapan
  2. 2.Departments of PathologyOsaka Medical Center for Cancer and Cardiovascular DiseasesJapan
  3. 3.Departments of Diagnostic RadiologyOsaka Medical Center for Cancer and Cardiovascular DiseasesJapan
  4. 4.Departments of Radiation OncologyOsaka Medical Center for Cancer and Cardiovascular DiseasesJapan

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