Abstract
A case of endocrine ductal carcinoma of the breast is presented. A 65-year-old woman was admitted with complaints of left breast mass and pain. Physical examination, mammography, ultrasonography, and computed tomography showed a mass 5 cm in diameter in the left breast suggestive of breast cancer, and incisional biopsy confirmed ductal carcinoma. Auchincloss’s mastectomy was performed. The tumor, 4.0×3.8 cm in size, consisted of a relatively uniform proliferation of tumor cells with round nuclei and abundant eosinophilic cytoplasm. Immunohistochemically, tumors cells were positive for chromogranin A, synaptophysin, and neuron-specific enolase. Endocrine ductal carcinoma with invasion was diagnosed. No lymph node metastasis was observed, and estrogen and progesterone receptors were positive.
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References
Enjoji M, Watanabe H: Histopathology of gastrointestinal carcinoids.Stomach & Intestine 10: 615–624, 1975.
Thomas RM, Baybick JH, Elsayed AM,et al: Gastric carcinoids. An immunohistochemical and clinicopathologic study of 104 patients.Cancer 73: 2053–2058, 1994.
Yoshida A, Yano M, Fujinaga Y,et al: Argentaffin carcinoid tumor of the rectum.Cancer 48: 2103–2106, 1981.
Brandt B II, Heintz SE, Rose EF,et al: Bronchial carcinoid tumors.Ann Thorac Surg 38: 63–65, 1984.
Capella C, Heitz PU, Höfler H,et al: Revised classification of neuroendocrine tumors of the lung, pancreas and gut.Virchows Arch 425: 547–560, 1995.
Cubilla AL, Woodruff JM: Primary carcinoid tumor of the breast. A report of eight patients.Am J Surg Pathol 1: 283–292, 1977.
Azzopardi JG, Muretto P, Goddeeris P,et al: “Carcinoid” tumors of the breast. The morphological spectrum of argyrophil carcinomas.Histopathology 6: 549–569, 1982.
Bussolati G, Papotti M, Sapino A,et al: Endocrine markers in argyrophilic carcinomas of the breast.Am J Surg Pathol 11: 248–256, 1987.
Toyoshima S: Mammary carcinoma with argyrophil cells.Cancer 52: 2129–2138, 1983.
Cross AS, Azzopardi JG, Krausz T,et al: A morphological and immunocytochemical study of a distinctive variant of ductal carcinoma in-situ of the breast.Histopathology 9: 21–37, 1985.
Tsang YW, Chan JKC: Endocrine ductal carcinoma in situ (DCIS) of the breast. A form of low-grade DCIS with distinctive clinicopathologic and biologic characteristics.Am J Surg Pathol 20: 921–943, 1996.
Paul Peter Rosen: Mammary carcinomas with endocrine features. In: Paul Peter Rosen ed, Rosen’s Breast Pathology, Lippincott-Raven Publishers, Philadelphia, pp431–435, 1997.
Cohle SD, Tschen JA, Smith FE,et al: ACTH-secreting carcinoma of the breast.Cancer 43: 2370–2376, 1979.
Woodard BH, Eisenbarth G, Wallace NR,et al: Adrenocorticotropin production by a mammary carcinoma.Cancer 47: 1823–1827, 1981.
Coombes RC, Easty GC, Detre SI,et al: Secretion of immunoreactive calcitonin by human breast carcinomas.Br Med J 4: 197–199, 1975.
Kaneko H, Hojo H, Ishikawa S,et al: Norepinephrineproducing tumors of bilateral breasts: a case report.Cancer 41: 2002–2007, 1978.
Mavligit GM, Cohen JL, Sherwood LM: Ectopic production of parathyroid hormone by carcinoma of the breast.N Engl J Med 285: 154–156, 1971.
Fetissof F, Dubois MP, Arbeille-Brassart B,et al: Argyrophilic cells in mammary carcinoma.Hum Pathol 14: 127–134, 1983.
Nesland JM, Holm R, Johannessen JV: A study of different markers for neuroendocrine differentiation in breast carcinomas.Pathol Res Pract 181: 524–530, 1986.
Partanen S, Syrjanen K: Argyrophilic cells in carcinoma of the female breast.Virchows Archiv 391: 45–51, 1981.
Scopsi L, Andreola S, Pilotti S,et al: Argyrophilia and granin (chromogranin/secretogranin) expression in female breast carcinomas. Their relationship to survival and other disease parameters.Am J Surg Pathol 16: 561–576, 1992.
Clayton F, Sibley RK, Ordonez NG,et al: Argyrophilic breast carcinomas. Evidence of lactational differentiation.Am J Surg Pathol 6: 323–333, 1982.
Uccini S, Monardo F, Paradiso P,et al: Synaptophysin in human breast carcinomas.Histopathology 18: 271–273, 1991.
Wilander E, Páhlman S, Sällström J,et al: Neuronspecific enolase expression and neuroendocrine differentiation in carcinomas of the breast.Arch Pathol Lab Med 111: 830–832, 1987.
Maluf HM, Koerner FC: Carcinomas of the breast with endocrine differentiation. A review.Virchows Arch 425: 449–457, 1994.
Maluf HM, Koerner FC: Solid papillary carcinoma of the breast: a form of intraductal carcinoma with endocrine differentiation frequently associated with mucinous carcinoma.Am J Surg Pathol 19: 1237–1244, 1995.
Ashworth MT, Haqqani MT: Endocrine variant of ductal carcinoma in situ of breast. Ultrastructural and light microscopical study.J Clin Pathol 39: 1355–1359, 1986.
Rasmussen BB, Rose C, Thorpe SM,et al: Argyrophilic cells in 202 human mucinous breast carcinomas. Relation to histopathologic and clinical factors.Am J Clin Pathol 84: 737–740, 1985.
Fisher ER, Palekar AS: Solid and mucinous varieties of so-called mammary carcinoid tumors.Am J Clin Pathol 72: 909–916, 1979.
Battersby S, Dely CJ, Hopkinson HE,et al: The nature of breast dense core granules. Chromogranin reactivity.Histopathology 20: 107–114, 1992.
Satake T, Matsuyama M: Endocrine cells in a normal breast and non-cancerous breast lesion.Acta Pathol Jpn 41: 874–878, 1991.
Laforga JBM, López JI: Breast carcinoma with endocrine features. Report of a case with cytologic and immunohistochemical studies.Acta Cytol 42: 1017–1021, 1998.
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Reprint requests lo Masafumi Inomata, Department of Surgery, Oita Medical Universily, 1-1 Idaigaoka, Hasama-machi, Oita 879–5593, Japan.
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Inomata, M., Kashima, K., Adachi, Y. et al. A case of endocrine ductal carcinoma of the breast. Breast Cancer 8, 250–253 (2001). https://doi.org/10.1007/BF02967518
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DOI: https://doi.org/10.1007/BF02967518